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2mxo

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<StructureSection load='2mxo' size='340' side='right'caption='[[2mxo]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
<StructureSection load='2mxo' size='340' side='right'caption='[[2mxo]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2mxo]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Chinese_bird_spider Chinese bird spider]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MXO OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2MXO FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2mxo]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Chinese_bird_spider Chinese bird spider]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MXO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MXO FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2mqf|2mqf]]</td></tr>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2mqf|2mqf]]</div></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2mxo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mxo OCA], [http://pdbe.org/2mxo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2mxo RCSB], [http://www.ebi.ac.uk/pdbsum/2mxo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2mxo ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mxo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mxo OCA], [https://pdbe.org/2mxo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mxo RCSB], [https://www.ebi.ac.uk/pdbsum/2mxo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mxo ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/H1A03_HAPHA H1A03_HAPHA]] Is a depressant toxin. Blocks the SCN2A/SCN1B (Nav1.2/Beta1) sodium channel receptor (IC(50) is 68 +-6 uM) and the insect sodium channel para/tipE (IC(50) is 4.3 +-0.3 uM), without altering the activation or inactivation kinetics.<ref>PMID:14675784</ref>
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[[https://www.uniprot.org/uniprot/H1A03_HAPHA H1A03_HAPHA]] Is a depressant toxin. Blocks the SCN2A/SCN1B (Nav1.2/Beta1) sodium channel receptor (IC(50) is 68 +-6 uM) and the insect sodium channel para/tipE (IC(50) is 4.3 +-0.3 uM), without altering the activation or inactivation kinetics.<ref>PMID:14675784</ref>
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<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==

Revision as of 09:03, 23 February 2022

NMR structure of spider toxin- G7W/N24S mutant of TRTX-Hhn2b

PDB ID 2mxo

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