6vg3

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Current revision (08:11, 11 October 2023) (edit) (undo)
 
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==Structure of unliganded, inactive PTK7 kinase domain==
==Structure of unliganded, inactive PTK7 kinase domain==
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<StructureSection load='6vg3' size='340' side='right'caption='[[6vg3]]' scene=''>
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<StructureSection load='6vg3' size='340' side='right'caption='[[6vg3]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6VG3 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6VG3 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6vg3]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6VG3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6VG3 FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6vg3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6vg3 OCA], [http://pdbe.org/6vg3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6vg3 RCSB], [http://www.ebi.ac.uk/pdbsum/6vg3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6vg3 ProSAT]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6vg3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6vg3 OCA], [https://pdbe.org/6vg3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6vg3 RCSB], [https://www.ebi.ac.uk/pdbsum/6vg3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6vg3 ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PTK7_HUMAN PTK7_HUMAN] Inactive tyrosine kinase involved in Wnt signaling pathway. Component of both the non-canonical (also known as the Wnt/planar cell polarity signaling) and the canonical Wnt signaling pathway. Functions in cell adhesion, cell migration, cell polarity, proliferation, actin cytoskeleton reorganization and apoptosis. Has a role in embryogenesis, epithelial tissue organization and angiogenesis.<ref>PMID:18471990</ref> <ref>PMID:20558616</ref> <ref>PMID:20837484</ref> <ref>PMID:21103379</ref> <ref>PMID:21132015</ref>
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== References ==
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<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Lemmon MA]]
[[Category: Lemmon MA]]

Current revision

Structure of unliganded, inactive PTK7 kinase domain

PDB ID 6vg3

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