1be9

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{{STRUCTURE_1be9| PDB=1be9 | SCENE= }}
{{STRUCTURE_1be9| PDB=1be9 | SCENE= }}
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'''THE THIRD PDZ DOMAIN FROM THE SYNAPTIC PROTEIN PSD-95 IN COMPLEX WITH A C-TERMINAL PEPTIDE DERIVED FROM CRIPT.'''
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===THE THIRD PDZ DOMAIN FROM THE SYNAPTIC PROTEIN PSD-95 IN COMPLEX WITH A C-TERMINAL PEPTIDE DERIVED FROM CRIPT.===
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==Overview==
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Modular PDZ domains, found in many cell junction-associated proteins, mediate the clustering of membrane ion channels by binding to their C-terminus. The X-ray crystallographic structures of the third PDZ domain from the synaptic protein PSD-95 in complex with and in the absence of its peptide ligand have been determined at 1.8 angstroms and 2.3 angstroms resolution, respectively. The structures reveal that a four-residue C-terminal stretch (X-Thr/Ser-X-Val-COO(-)) engages the PDZ domain through antiparallel main chain interactions with a beta sheet of the domain. Recognition of the terminal carboxylate group of the peptide is conferred by a cradle of main chain amides provided by a Gly-Leu-Gly-Phe loop as well as by an arginine side chain. Specific side chain interactions and a prominent hydrophobic pocket explain the selective recognition of the C-terminal consensus sequence.
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(as it appears on PubMed at http://www.pubmed.gov), where 8674113 is the PubMed ID number.
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{{ABSTRACT_PUBMED_8674113}}
==About this Structure==
==About this Structure==
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[[Category: Peptide recognition]]
[[Category: Peptide recognition]]
[[Category: Protein localization]]
[[Category: Protein localization]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 11:24:12 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 18:57:50 2008''

Revision as of 15:57, 30 June 2008

Image:1be9.png

Template:STRUCTURE 1be9

THE THIRD PDZ DOMAIN FROM THE SYNAPTIC PROTEIN PSD-95 IN COMPLEX WITH A C-TERMINAL PEPTIDE DERIVED FROM CRIPT.

Template:ABSTRACT PUBMED 8674113

About this Structure

1BE9 is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

Crystal structures of a complexed and peptide-free membrane protein-binding domain: molecular basis of peptide recognition by PDZ., Doyle DA, Lee A, Lewis J, Kim E, Sheng M, MacKinnon R, Cell. 1996 Jun 28;85(7):1067-76. PMID:8674113

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