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{{STRUCTURE_1beg| PDB=1beg | SCENE= }}
{{STRUCTURE_1beg| PDB=1beg | SCENE= }}
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'''STRUCTURE OF FUNGAL ELICITOR, NMR, 18 STRUCTURES'''
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===STRUCTURE OF FUNGAL ELICITOR, NMR, 18 STRUCTURES===
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==Overview==
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Cryptogein belongs to a new family of 10-kDa proteins called elicitins. Elicitins are necrotic and signaling proteins secreted by Phytophthora spp. responsible for the incompatible reaction and systemic hypersensitive-like necroses of diverse plant species leading to resistance against fungal or bacterial plant pathogens. The solution structure of beta cryptogein from Phytophthora cryptogea fungus was determined by using multidimensional heteronuclear nuclear magnetic resonance spectroscopy. A set of 18 structures was calculated using 1360 NOE-derived distance restraints and 40 dihedral angle restraints obtained from 3JHNH alpha couplings. The RMS deviation from the mean structure is 0.87 +/- 0.14 A for backbone atoms and 1.34 +/- 0.14 A for all the non-hydrogen atoms of residues 2 to 98. The structure of beta cryptogein reveals a novel protein fold, with five helices and a double-stranded beta-sheet facing an omega-loop. One edge of the beta-sheet and the adjacent face of the omega-loop form a hydrophobic cavity. This cavity made of highly conserved residues represents a plausible binding site. Residue 13, which has been identified from directed mutagenesis and natural sequence comparison studies as a key amino acid involved in the differential control of necrosis, is surface exposed and could contribute to the binding to a ligand or a receptor. The solution structure is close to the X-ray structure, with slight differences lightly due to the crystal packing.
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(as it appears on PubMed at http://www.pubmed.gov), where 9385630 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9385630}}
==About this Structure==
==About this Structure==
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1BEG is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Phytophthora_cryptogea Phytophthora cryptogea]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BEG OCA].
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1BEG is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Phytophthora_cryptogea Phytophthora cryptogea]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BEG OCA].
==Reference==
==Reference==
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[[Category: Signal]]
[[Category: Signal]]
[[Category: Signalling protein]]
[[Category: Signalling protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 11:24:43 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 18:58:34 2008''

Revision as of 15:58, 30 June 2008

Image:1beg.png

Template:STRUCTURE 1beg

STRUCTURE OF FUNGAL ELICITOR, NMR, 18 STRUCTURES

Template:ABSTRACT PUBMED 9385630

About this Structure

1BEG is a Single protein structure of sequence from Phytophthora cryptogea. Full experimental information is available from OCA.

Reference

Three-dimensional solution structure of beta cryptogein, a beta elicitin secreted by a phytopathogenic fungus Phytophthora cryptogea., Fefeu S, Bouaziz S, Huet JC, Pernollet JC, Guittet E, Protein Sci. 1997 Nov;6(11):2279-84. PMID:9385630

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