1bg2

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==Overview==
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{{ABSTRACT_8606779}}
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Kinesin is the founding member of a superfamily of microtubule based motor proteins that perform force-generating tasks such as organelle transport and chromosome segregation. It has two identical approximately 960-amino-acid chains containing an amino-terminal globular motor domain, a central alpha-helical region that enables dimer formation through a coiled-coil, and a carboxy-terminal tail domain that binds light chains and possibly an organelle receptor. The kinesin motor domain of approximately 340 amino acids, which can produce movement in vitro, is much smaller than that of myosin (approximately 850 amino acids) and dynein (1,000 amino acids), and is the smallest known molecular motor. Here, we report the crystal structure of the human kinesin motor domain with bound ADP determined to 1.8-A resolution by X-ray crystallography. The motor consists primarily of a single alpha/beta arrowhead-shaped domain with dimensions of 70 x 45 x 45 A. Unexpectedly, it has a striking structural similarity to the core of the catalytic domain of the actin-based motor myosin. Although kinesin and myosin have virtually no amino-acid sequence++ identity, and exhibit distinct enzymatic and motile properties, our results suggest that these two classes of mechanochemical enzymes evolved from a common ancestor and share a similar force-generating strategy.
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==About this Structure==
==About this Structure==
1BG2 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. The following page contains interesting information on the relation of 1BG2 with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb64_1.html Kinesin]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BG2 OCA].
1BG2 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. The following page contains interesting information on the relation of 1BG2 with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb64_1.html Kinesin]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BG2 OCA].
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==Reference==
 
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Crystal structure of the kinesin motor domain reveals a structural similarity to myosin., Kull FJ, Sablin EP, Lau R, Fletterick RJ, Vale RD, Nature. 1996 Apr 11;380(6574):550-5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8606779 8606779]
 
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Kinesin]]
[[Category: Kinesin]]
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[[Category: Microtubule associated]]
[[Category: Microtubule associated]]
[[Category: Motor protein]]
[[Category: Motor protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 11:27:55 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jun 26 17:04:51 2008''

Revision as of 14:04, 26 June 2008

Image:1bg2.png

Template:STRUCTURE 1bg2

HUMAN UBIQUITOUS KINESIN MOTOR DOMAIN


Template:ABSTRACT 8606779

About this Structure

1BG2 is a Single protein structure of sequence from Homo sapiens. The following page contains interesting information on the relation of 1BG2 with [Kinesin]. Full crystallographic information is available from OCA.

Page seeded by OCA on Thu Jun 26 17:04:51 2008

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