1bg3

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{{STRUCTURE_1bg3| PDB=1bg3 | SCENE= }}
{{STRUCTURE_1bg3| PDB=1bg3 | SCENE= }}
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'''RAT BRAIN HEXOKINASE TYPE I COMPLEX WITH GLUCOSE AND INHIBITOR GLUCOSE-6-PHOSPHATE'''
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===RAT BRAIN HEXOKINASE TYPE I COMPLEX WITH GLUCOSE AND INHIBITOR GLUCOSE-6-PHOSPHATE===
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==Overview==
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We have determined the structures of the glucose-6-phosphate (G6P)-inhibitable 100,000 Mr Type I hexokinase from rat and the G6P-sensitive 50,000 Mr hexokinase from Schistosoma mansoni at a resolution of 2.8 and 2.6 A respectively. The structures define the glucose and G6P binding sites in these enzymes, suggest the mechanisms of intradomain G6P inhibition and activity loss in the Type I hexokinase N-terminal half, and reveal the structure of the membrane targeting motif that integrates the Type I hexokinase into the outer mitochondrial membrane.
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(as it appears on PubMed at http://www.pubmed.gov), where 9665168 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9665168}}
==About this Structure==
==About this Structure==
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[[Category: Hexokinase]]
[[Category: Hexokinase]]
[[Category: Phosphotransferase]]
[[Category: Phosphotransferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 19:05:04 2008''

Revision as of 16:05, 30 June 2008

Image:1bg3.png

Template:STRUCTURE 1bg3

RAT BRAIN HEXOKINASE TYPE I COMPLEX WITH GLUCOSE AND INHIBITOR GLUCOSE-6-PHOSPHATE

Template:ABSTRACT PUBMED 9665168

About this Structure

1BG3 is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

The structure of mammalian hexokinase-1., Mulichak AM, Wilson JE, Padmanabhan K, Garavito RM, Nat Struct Biol. 1998 Jul;5(7):555-60. PMID:9665168

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