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1bg7

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[[Image:1bg7.gif|left|200px]]
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{{Seed}}
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[[Image:1bg7.png|left|200px]]
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{{STRUCTURE_1bg7| PDB=1bg7 | SCENE= }}
{{STRUCTURE_1bg7| PDB=1bg7 | SCENE= }}
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'''LOCALIZED UNFOLDING AT THE JUNCTION OF THREE FERRITIN SUBUNITS. A MECHANISM FOR IRON RELEASE?'''
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===LOCALIZED UNFOLDING AT THE JUNCTION OF THREE FERRITIN SUBUNITS. A MECHANISM FOR IRON RELEASE?===
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==Overview==
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How and where iron exits from ferritin for cellular use is unknown. Twenty-four protein subunits create a cavity in ferritin where iron is concentrated &gt;10(11)-fold as a mineral. Proline substitution for conserved leucine 134 (L134P) allowed normal assembly but increased iron exit rates. X-ray crystallography of H-L134P ferritin revealed localized unfolding at the 3-fold axis, also iron entry sites, consistent with shared use sites for iron exit and entry. The junction of three ferritin subunits appears to be a dynamic aperture with a "shutter" that cytoplasmic factors might open or close to regulate iron release in vivo.
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The line below this paragraph, {{ABSTRACT_PUBMED_9668036}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 9668036 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9668036}}
==About this Structure==
==About this Structure==
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[[Category: Ferritin]]
[[Category: Ferritin]]
[[Category: Iron storage]]
[[Category: Iron storage]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 11:28:24 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 19:05:45 2008''

Revision as of 16:05, 30 June 2008

Image:1bg7.png

Template:STRUCTURE 1bg7

LOCALIZED UNFOLDING AT THE JUNCTION OF THREE FERRITIN SUBUNITS. A MECHANISM FOR IRON RELEASE?

Template:ABSTRACT PUBMED 9668036

About this Structure

1BG7 is a Single protein structure of sequence from Rana catesbeiana. Full crystallographic information is available from OCA.

Reference

Localized unfolding at the junction of three ferritin subunits. A mechanism for iron release?, Takagi H, Shi D, Ha Y, Allewell NM, Theil EC, J Biol Chem. 1998 Jul 24;273(30):18685-8. PMID:9668036

Page seeded by OCA on Mon Jun 30 19:05:45 2008

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