This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


5j2u

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (10:43, 6 September 2023) (edit) (undo)
 
Line 3: Line 3:
<StructureSection load='5j2u' size='340' side='right'caption='[[5j2u]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
<StructureSection load='5j2u' size='340' side='right'caption='[[5j2u]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[5j2u]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Bovin Bovin], [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5J2U OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5J2U FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[5j2u]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5J2U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5J2U FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6DO:(2~{S})-2-[[(2~{R},3~{R})-3-METHOXY-3-[(2~{S})-1-[(3~{R},4~{S},5~{S})-3-METHOXY-5-METHYL-4-[METHYL-[(2~{S})-3-METHYL-2-[[(2~{S})-3-METHYL-2-(METHYLAMINO)BUTANOYL]AMINO]BUTANOYL]AMINO]HEPTANOYL]PYRROLIDIN-2-YL]-2-METHYL-PROPANOYL]AMINO]-3-PHENYL-PROPANOIC+ACID'>6DO</scene>, <scene name='pdbligand=ACP:PHOSPHOMETHYLPHOSPHONIC+ACID+ADENYLATE+ESTER'>ACP</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
-
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5iyz|5iyz]]</td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6DO:(2~{S})-2-[[(2~{R},3~{R})-3-METHOXY-3-[(2~{S})-1-[(3~{R},4~{S},5~{S})-3-METHOXY-5-METHYL-4-[METHYL-[(2~{S})-3-METHYL-2-[[(2~{S})-3-METHYL-2-(METHYLAMINO)BUTANOYL]AMINO]BUTANOYL]AMINO]HEPTANOYL]PYRROLIDIN-2-YL]-2-METHYL-PROPANOYL]AMINO]-3-PHENYL-PROPANOIC+ACID'>6DO</scene>, <scene name='pdbligand=ACP:PHOSPHOMETHYLPHOSPHONIC+ACID+ADENYLATE+ESTER'>ACP</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Stmn4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat]), TUBB2B ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9913 BOVIN])</td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5j2u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5j2u OCA], [https://pdbe.org/5j2u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5j2u RCSB], [https://www.ebi.ac.uk/pdbsum/5j2u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5j2u ProSAT]</span></td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5j2u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5j2u OCA], [http://pdbe.org/5j2u PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5j2u RCSB], [http://www.ebi.ac.uk/pdbsum/5j2u PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5j2u ProSAT]</span></td></tr>
+
</table>
</table>
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/TBB2B_BOVIN TBB2B_BOVIN]] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity). [[http://www.uniprot.org/uniprot/TBA1B_BOVIN TBA1B_BOVIN]] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. [[http://www.uniprot.org/uniprot/STMN4_RAT STMN4_RAT]] Exhibits microtubule-destabilizing activity.<ref>PMID:15039434</ref> <ref>PMID:12111843</ref> <ref>PMID:15014504</ref>
+
[https://www.uniprot.org/uniprot/TBA1B_BOVIN TBA1B_BOVIN] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 25: Line 24:
*[[Tubulin 3D Structures|Tubulin 3D Structures]]
*[[Tubulin 3D Structures|Tubulin 3D Structures]]
*[[Tubulin tyrosine ligase|Tubulin tyrosine ligase]]
*[[Tubulin tyrosine ligase|Tubulin tyrosine ligase]]
-
*[[User:Alisa Cario|User:Alisa Cario]]
 
== References ==
== References ==
<references/>
<references/>
Line 31: Line 29:
</StructureSection>
</StructureSection>
[[Category: Bos taurus]]
[[Category: Bos taurus]]
-
[[Category: Bovin]]
 
-
[[Category: Buffalo rat]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
-
[[Category: Bargsten, K]]
+
[[Category: Rattus norvegicus]]
-
[[Category: Doronina, S]]
+
[[Category: Bargsten K]]
-
[[Category: Prota, A E]]
+
[[Category: Doronina S]]
-
[[Category: Steinmetz, M O]]
+
[[Category: Prota AE]]
-
[[Category: Sussman, D]]
+
[[Category: Steinmetz MO]]
-
[[Category: Waight, A B]]
+
[[Category: Sussman D]]
-
[[Category: Cell cycle]]
+
[[Category: Waight AB]]
-
[[Category: Cytoskeleton]]
+
-
[[Category: Microtubule]]
+
-
[[Category: Tubulin fold]]
+

Current revision

Tubulin-MMAF complex

PDB ID 5j2u

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/5j2u"
Personal tools