5j2u

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<StructureSection load='5j2u' size='340' side='right'caption='[[5j2u]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
<StructureSection load='5j2u' size='340' side='right'caption='[[5j2u]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5j2u]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Bovin Bovin], [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5J2U OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5J2U FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5j2u]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5J2U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5J2U FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6DO:(2~{S})-2-[[(2~{R},3~{R})-3-METHOXY-3-[(2~{S})-1-[(3~{R},4~{S},5~{S})-3-METHOXY-5-METHYL-4-[METHYL-[(2~{S})-3-METHYL-2-[[(2~{S})-3-METHYL-2-(METHYLAMINO)BUTANOYL]AMINO]BUTANOYL]AMINO]HEPTANOYL]PYRROLIDIN-2-YL]-2-METHYL-PROPANOYL]AMINO]-3-PHENYL-PROPANOIC+ACID'>6DO</scene>, <scene name='pdbligand=ACP:PHOSPHOMETHYLPHOSPHONIC+ACID+ADENYLATE+ESTER'>ACP</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5iyz|5iyz]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6DO:(2~{S})-2-[[(2~{R},3~{R})-3-METHOXY-3-[(2~{S})-1-[(3~{R},4~{S},5~{S})-3-METHOXY-5-METHYL-4-[METHYL-[(2~{S})-3-METHYL-2-[[(2~{S})-3-METHYL-2-(METHYLAMINO)BUTANOYL]AMINO]BUTANOYL]AMINO]HEPTANOYL]PYRROLIDIN-2-YL]-2-METHYL-PROPANOYL]AMINO]-3-PHENYL-PROPANOIC+ACID'>6DO</scene>, <scene name='pdbligand=ACP:PHOSPHOMETHYLPHOSPHONIC+ACID+ADENYLATE+ESTER'>ACP</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Stmn4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat]), TUBB2B ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9913 BOVIN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5j2u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5j2u OCA], [https://pdbe.org/5j2u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5j2u RCSB], [https://www.ebi.ac.uk/pdbsum/5j2u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5j2u ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5j2u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5j2u OCA], [http://pdbe.org/5j2u PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5j2u RCSB], [http://www.ebi.ac.uk/pdbsum/5j2u PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5j2u ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/TBB2B_BOVIN TBB2B_BOVIN]] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity). [[http://www.uniprot.org/uniprot/TBA1B_BOVIN TBA1B_BOVIN]] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. [[http://www.uniprot.org/uniprot/STMN4_RAT STMN4_RAT]] Exhibits microtubule-destabilizing activity.<ref>PMID:15039434</ref> <ref>PMID:12111843</ref> <ref>PMID:15014504</ref>
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[https://www.uniprot.org/uniprot/TBA1B_BOVIN TBA1B_BOVIN] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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*[[Tubulin 3D Structures|Tubulin 3D Structures]]
*[[Tubulin 3D Structures|Tubulin 3D Structures]]
*[[Tubulin tyrosine ligase|Tubulin tyrosine ligase]]
*[[Tubulin tyrosine ligase|Tubulin tyrosine ligase]]
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*[[User:Alisa Cario|User:Alisa Cario]]
 
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Bos taurus]]
[[Category: Bos taurus]]
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[[Category: Bovin]]
 
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[[Category: Buffalo rat]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Bargsten, K]]
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[[Category: Rattus norvegicus]]
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[[Category: Doronina, S]]
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[[Category: Bargsten K]]
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[[Category: Prota, A E]]
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[[Category: Doronina S]]
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[[Category: Steinmetz, M O]]
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[[Category: Prota AE]]
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[[Category: Sussman, D]]
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[[Category: Steinmetz MO]]
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[[Category: Waight, A B]]
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[[Category: Sussman D]]
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[[Category: Cell cycle]]
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[[Category: Waight AB]]
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[[Category: Cytoskeleton]]
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[[Category: Microtubule]]
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[[Category: Tubulin fold]]
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Revision as of 10:43, 6 September 2023

Tubulin-MMAF complex

PDB ID 5j2u

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