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5j58

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<StructureSection load='5j58' size='340' side='right'caption='[[5j58]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
<StructureSection load='5j58' size='340' side='right'caption='[[5j58]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5j58]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Tryb2 Tryb2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5J58 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5J58 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5j58]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_brucei_brucei_TREU927 Trypanosoma brucei brucei TREU927]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5J58 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5J58 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MET:METHIONINE'>MET</scene>, <scene name='pdbligand=N56:(3S)-1-(5-CHLORO-1H-IMIDAZO[4,5-B]PYRIDIN-2-YL)-N-[(3,5-DICHLOROPHENYL)METHYL]PIPERIDIN-3-AMINE'>N56</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Tb10.70.6470 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=185431 TRYB2])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MET:METHIONINE'>MET</scene>, <scene name='pdbligand=N56:(3S)-1-(5-CHLORO-1H-IMIDAZO[4,5-B]PYRIDIN-2-YL)-N-[(3,5-DICHLOROPHENYL)METHYL]PIPERIDIN-3-AMINE'>N56</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Methionine--tRNA_ligase Methionine--tRNA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.10 6.1.1.10] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5j58 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5j58 OCA], [https://pdbe.org/5j58 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5j58 RCSB], [https://www.ebi.ac.uk/pdbsum/5j58 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5j58 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5j58 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5j58 OCA], [http://pdbe.org/5j58 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5j58 RCSB], [http://www.ebi.ac.uk/pdbsum/5j58 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5j58 ProSAT]</span></td></tr>
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</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q38C91_TRYB2 Q38C91_TRYB2]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Methionine--tRNA ligase]]
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[[Category: Trypanosoma brucei brucei TREU927]]
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[[Category: Tryb2]]
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[[Category: Barros-Alvarez X]]
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[[Category: Barros-Alvarez, X]]
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[[Category: Hol WGJ]]
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[[Category: Hol, W G.J]]
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[[Category: Inhibitor]]
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[[Category: Ligase]]
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[[Category: Ligase-ligase inhibitor complex]]
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[[Category: Methionine]]
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[[Category: Synthetase]]
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Revision as of 10:48, 6 September 2023

Trypanosoma brucei methionyl-tRNA synthetase in complex with inhibitor (Chem 1856)

PDB ID 5j58

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