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| | <StructureSection load='5j7e' size='340' side='right'caption='[[5j7e]], [[Resolution|resolution]] 1.90Å' scene=''> | | <StructureSection load='5j7e' size='340' side='right'caption='[[5j7e]], [[Resolution|resolution]] 1.90Å' scene=''> |
| | == Structural highlights == | | == Structural highlights == |
| - | <table><tr><td colspan='2'>[[5j7e]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5J7E OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5J7E FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[5j7e]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5J7E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5J7E FirstGlance]. <br> |
| - | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">KCNH1, EAG, EAG1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9Å</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5j7e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5j7e OCA], [http://pdbe.org/5j7e PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5j7e RCSB], [http://www.ebi.ac.uk/pdbsum/5j7e PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5j7e ProSAT]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5j7e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5j7e OCA], [https://pdbe.org/5j7e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5j7e RCSB], [https://www.ebi.ac.uk/pdbsum/5j7e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5j7e ProSAT]</span></td></tr> |
| | </table> | | </table> |
| | == Disease == | | == Disease == |
| - | [[http://www.uniprot.org/uniprot/KCNH1_HUMAN KCNH1_HUMAN]] The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. | + | [https://www.uniprot.org/uniprot/KCNH1_HUMAN KCNH1_HUMAN] The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. |
| | == Function == | | == Function == |
| - | [[http://www.uniprot.org/uniprot/KCNH1_HUMAN KCNH1_HUMAN]] Pore-forming (alpha) subunit of a voltage-gated delayed rectifier potassium channel (PubMed:22732247). Channel properties may be modulated by subunit assembly, but not by cyclic nucleotides (By similarity). Mediates IK(NI) current in myoblasts (PubMed:9738473). Involved in the regulation of cell proliferation and differentiation, in particular adipogenic and osteogenic differentiation in bone marrow-derived mesenchymal stem cells (MSCs) (PubMed:23881642).[UniProtKB:Q60603]<ref>PMID:22732247</ref> <ref>PMID:23881642</ref> <ref>PMID:9738473</ref> | + | [https://www.uniprot.org/uniprot/KCNH1_HUMAN KCNH1_HUMAN] Pore-forming (alpha) subunit of a voltage-gated delayed rectifier potassium channel (PubMed:22732247). Channel properties may be modulated by subunit assembly, but not by cyclic nucleotides (By similarity). Mediates IK(NI) current in myoblasts (PubMed:9738473). Involved in the regulation of cell proliferation and differentiation, in particular adipogenic and osteogenic differentiation in bone marrow-derived mesenchymal stem cells (MSCs) (PubMed:23881642).[UniProtKB:Q60603]<ref>PMID:22732247</ref> <ref>PMID:23881642</ref> <ref>PMID:9738473</ref> |
| | | | |
| | ==See Also== | | ==See Also== |
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| | __TOC__ | | __TOC__ |
| | </StructureSection> | | </StructureSection> |
| - | [[Category: Human]] | + | [[Category: Homo sapiens]] |
| | [[Category: Large Structures]] | | [[Category: Large Structures]] |
| - | [[Category: Juan, S]] | + | [[Category: Juan S]] |
| - | [[Category: Xiaohong, Q]] | + | [[Category: Xiaohong Q]] |
| - | [[Category: Xue, T]] | + | [[Category: Xue T]] |
| - | [[Category: Ether-a-go-go channel]]
| + | |
| - | [[Category: Kcnh channel]]
| + | |
| - | [[Category: Pas domain]]
| + | |
| - | [[Category: Transport protein]]
| + | |
| Structural highlights
Disease
KCNH1_HUMAN The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.
Function
KCNH1_HUMAN Pore-forming (alpha) subunit of a voltage-gated delayed rectifier potassium channel (PubMed:22732247). Channel properties may be modulated by subunit assembly, but not by cyclic nucleotides (By similarity). Mediates IK(NI) current in myoblasts (PubMed:9738473). Involved in the regulation of cell proliferation and differentiation, in particular adipogenic and osteogenic differentiation in bone marrow-derived mesenchymal stem cells (MSCs) (PubMed:23881642).[UniProtKB:Q60603][1] [2] [3]
See Also
References
- ↑ Marques-Carvalho MJ, Sahoo N, Muskett FW, Vieira-Pires RS, Gabant G, Cadene M, Schonherr R, Morais-Cabral JH. Structural, Biochemical, and Functional Characterization of the Cyclic Nucleotide Binding Homology Domain from the Mouse EAG1 Potassium Channel. J Mol Biol. 2012 Jun 23. PMID:22732247 doi:10.1016/j.jmb.2012.06.025
- ↑ Zhang YY, Yue J, Che H, Sun HY, Tse HF, Li GR. BKCa and hEag1 channels regulate cell proliferation and differentiation in human bone marrow-derived mesenchymal stem cells. J Cell Physiol. 2014 Feb;229(2):202-12. doi: 10.1002/jcp.24435. PMID:23881642 doi:http://dx.doi.org/10.1002/jcp.24435
- ↑ Occhiodoro T, Bernheim L, Liu JH, Bijlenga P, Sinnreich M, Bader CR, Fischer-Lougheed J. Cloning of a human ether-a-go-go potassium channel expressed in myoblasts at the onset of fusion. FEBS Lett. 1998 Aug 28;434(1-2):177-82. PMID:9738473
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