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| - | | + | REMOVED: The PDB entry 5jm5 was removed. |
| - | ==Crystal structure of AKR1C3 complexed with a pro-drug==
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| - | <StructureSection load='5jm5' size='340' side='right'caption='[[5jm5]], [[Resolution|resolution]] 1.99Å' scene=''>
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| - | == Structural highlights ==
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| - | <table><tr><td colspan='2'>[[5jm5]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JM5 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5JM5 FirstGlance]. <br>
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| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6LG:(1R)-1-{3-[3-(DIMETHYLCARBAMOYL)PHENOXY]-4-NITROPHENYL}ETHYL+BIS[(AZIRIDIN-1-YL)]PHOSPHINATE'>6LG</scene>, <scene name='pdbligand=6NY:3-{2-(HYDROXYAMINO)-5-[(1S)-1-HYDROXYETHYL]PHENOXY}-N,N-DIMETHYLBENZAMIDE'>6NY</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
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| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">AKR1C3, DDH1, HSD17B5, KIAA0119, PGFS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5jm5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jm5 OCA], [http://pdbe.org/5jm5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5jm5 RCSB], [http://www.ebi.ac.uk/pdbsum/5jm5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5jm5 ProSAT]</span></td></tr>
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| - | </table>
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| - | == Function ==
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| - | [[http://www.uniprot.org/uniprot/AK1C3_HUMAN AK1C3_HUMAN]] Catalyzes the conversion of aldehydes and ketones to alcohols. Catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ) and the oxidation of 9-alpha,11-beta-PGF2 to PGD2. Functions as a bi-directional 3-alpha-, 17-beta- and 20-alpha HSD. Can interconvert active androgens, estrogens and progestins with their cognate inactive metabolites. Preferentially transforms androstenedione (4-dione) to testosterone.
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| - | | + | |
| - | ==See Also==
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| - | *[[Prostaglandin F synthase|Prostaglandin F synthase]]
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| - | __TOC__
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| - | </StructureSection>
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| - | [[Category: Human]]
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| - | [[Category: Large Structures]]
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| - | [[Category: Li, Q]]
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| - | [[Category: Wang, C]]
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| - | [[Category: Wang, Z]]
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| - | [[Category: Xie, W]]
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| - | [[Category: Akr1c3]]
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| - | [[Category: Inhibitor]]
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| - | [[Category: Liver cancer]]
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| - | [[Category: Oxidoreductase-oxidoreductase inhibitor complex]]
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| - | [[Category: Pro-drug]]
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