1bi5

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[[Image:1bi5.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_1bi5| PDB=1bi5 | SCENE= }}
{{STRUCTURE_1bi5| PDB=1bi5 | SCENE= }}
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'''CHALCONE SYNTHASE FROM ALFALFA'''
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===CHALCONE SYNTHASE FROM ALFALFA===
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==Overview==
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Chalcone synthase (CHS) is pivotal for the biosynthesis of flavonoid antimicrobial phytoalexins and anthocyanin pigments in plants. It produces chalcone by condensing one p-coumaroyl- and three malonyl-coenzyme A thioesters into a polyketide reaction intermediate that cyclizes. The crystal structures of CHS alone and complexed with substrate and product analogs reveal the active site architecture that defines the sequence and chemistry of multiple decarboxylation and condensation reactions and provides a molecular understanding of the cyclization reaction leading to chalcone synthesis. The structure of CHS complexed with resveratrol also suggests how stilbene synthase, a related enzyme, uses the same substrates and an alternate cyclization pathway to form resveratrol. By using the three-dimensional structure and the large database of CHS-like sequences, we can identify proteins likely to possess novel substrate and product specificity. The structure elucidates the chemical basis of plant polyketide biosynthesis and provides a framework for engineering CHS-like enzymes to produce new products.
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(as it appears on PubMed at http://www.pubmed.gov), where 10426957 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10426957}}
==About this Structure==
==About this Structure==
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[[Category: Chalcone biosynthesis]]
[[Category: Chalcone biosynthesis]]
[[Category: Polyketide synthase]]
[[Category: Polyketide synthase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 19:12:10 2008''

Revision as of 16:12, 30 June 2008

Image:1bi5.png

Template:STRUCTURE 1bi5

CHALCONE SYNTHASE FROM ALFALFA

Template:ABSTRACT PUBMED 10426957

About this Structure

1BI5 is a Single protein structure of sequence from Medicago sativa. Full crystallographic information is available from OCA.

Reference

Structure of chalcone synthase and the molecular basis of plant polyketide biosynthesis., Ferrer JL, Jez JM, Bowman ME, Dixon RA, Noel JP, Nat Struct Biol. 1999 Aug;6(8):775-84. PMID:10426957

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