Phospholipase A2 homolog
From Proteopedia
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== Structural highlights == | == Structural highlights == | ||
| - | The complex between PLA2 homolog and the inhibitor suramin shows the inhibitor interacting with both monomers. The location of PLA2 active site conserved Asp49 which is substituted by Lys in PLA2 homologs thus rendering PLA2 | + | The complex between PLA2 homolog and the inhibitor suramin shows the inhibitor interacting with both monomers. The location of PLA2 active site conserved Asp49 which is substituted by Lys in PLA2 homologs thus rendering PLA2<ref>PMID:26457430</ref>. |
</StructureSection> | </StructureSection> | ||
Revision as of 08:55, 17 June 2020
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3D structures of phospholipase A2 homolog
Updated on 17-June-2020
References
- ↑ Lomonte B, Angulo Y, Sasa M, Gutierrez JM. The phospholipase A2 homologues of snake venoms: biological activities and their possible adaptive roles. Protein Pept Lett. 2009;16(8):860-76. doi: 10.2174/092986609788923356. PMID:19689412 doi:http://dx.doi.org/10.2174/092986609788923356
- ↑ Salvador GH, Dreyer TR, Cavalcante WL, Matioli FF, Dos Santos JI, Velazquez-Campoy A, Gallacci M, Fontes MR. Structural and functional evidence for membrane docking and disruption sites on phospholipase A2-like proteins revealed by complexation with the inhibitor suramin. Acta Crystallogr D Biol Crystallogr. 2015 Oct;71(Pt 10):2066-78. doi:, 10.1107/S1399004715014443. Epub 2015 Sep 26. PMID:26457430 doi:http://dx.doi.org/10.1107/S1399004715014443
