1bic

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[[Image:1bic.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_1bic| PDB=1bic | SCENE= }}
{{STRUCTURE_1bic| PDB=1bic | SCENE= }}
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'''CRYSTALLOGRAPHIC ANALYSIS OF THR-200-> HIS HUMAN CARBONIC ANHYDRASE II AND ITS COMPLEX WITH THE SUBSTRATE, HCO3-'''
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===CRYSTALLOGRAPHIC ANALYSIS OF THR-200-> HIS HUMAN CARBONIC ANHYDRASE II AND ITS COMPLEX WITH THE SUBSTRATE, HCO3-===
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==Overview==
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A complex of carbonic anhydrase (CA) with one of its substrates, bicarbonate, has been studied crystallographically. Human isoenzyme II was mutated at position 200 from threonine to histidine, which results in higher affinity for bicarbonate. The HCO3- ion binds in the active site to the zinc ion as a pseudo-bidentate ligand which gives the metal a coordination geometry between tetrahedral and trigonal bipyramide. The water/hydroxide normally bound with tetrahedral coordination to the zinc is probably replaced by the OH group of the bicarbonate ion. The importance of residues Thr-199 and Glu-106 in controlling the binding orientation of HCO3- is discussed as well as the catalytic mechanism. Both the complex as well as the uncomplexed mutant were studied at 1.9 A resolution.
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(as it appears on PubMed at http://www.pubmed.gov), where 8451242 is the PubMed ID number.
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{{ABSTRACT_PUBMED_8451242}}
==About this Structure==
==About this Structure==
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[[Category: Vidgren, J.]]
[[Category: Vidgren, J.]]
[[Category: Xue, Y.]]
[[Category: Xue, Y.]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 11:33:02 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 19:12:44 2008''

Revision as of 16:12, 30 June 2008

Image:1bic.png

Template:STRUCTURE 1bic

CRYSTALLOGRAPHIC ANALYSIS OF THR-200-> HIS HUMAN CARBONIC ANHYDRASE II AND ITS COMPLEX WITH THE SUBSTRATE, HCO3-

Template:ABSTRACT PUBMED 8451242

About this Structure

1BIC is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystallographic analysis of Thr-200-->His human carbonic anhydrase II and its complex with the substrate, HCO3-., Xue Y, Vidgren J, Svensson LA, Liljas A, Jonsson BH, Lindskog S, Proteins. 1993 Jan;15(1):80-7. PMID:8451242

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