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6lug
From Proteopedia
(Difference between revisions)
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==Crystal structure of N(omega)-hydroxy-L-arginine hydrolase== | ==Crystal structure of N(omega)-hydroxy-L-arginine hydrolase== | ||
| - | <StructureSection load='6lug' size='340' side='right'caption='[[6lug]]' scene=''> | + | <StructureSection load='6lug' size='340' side='right'caption='[[6lug]], [[Resolution|resolution]] 1.90Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6LUG OCA]. For a <b>guided tour on the structure components</b> use [ | + | <table><tr><td colspan='2'>[[6lug]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_lavendulae Streptomyces lavendulae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6LUG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6LUG FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9Å</td></tr> |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6lug FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6lug OCA], [https://pdbe.org/6lug PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6lug RCSB], [https://www.ebi.ac.uk/pdbsum/6lug PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6lug ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/DCSB_STRLA DCSB_STRLA] Involved in the biosynthesis of the antibiotic D-cycloserine (DCS), a cyclic structural analog of D-alanine, used as an antitubercular agent. Catalyzes the hydrolysis of N(omega)-hydroxy-L-arginine (NHA) to yield hydroxyurea (HU) and L-ornithine.<ref>PMID:20086163</ref> <ref>PMID:22547619</ref> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| + | [[Category: Streptomyces lavendulae]] | ||
[[Category: Matoba Y]] | [[Category: Matoba Y]] | ||
[[Category: Oda K]] | [[Category: Oda K]] | ||
Current revision
Crystal structure of N(omega)-hydroxy-L-arginine hydrolase
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