6top
From Proteopedia
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==Structure of the PorE C-terminal domain, a protein of T9SS from Porphyromonas gingivalis== | ==Structure of the PorE C-terminal domain, a protein of T9SS from Porphyromonas gingivalis== | ||
| - | <StructureSection load='6top' size='340' side='right'caption='[[6top]]' scene=''> | + | <StructureSection load='6top' size='340' side='right'caption='[[6top]], [[Resolution|resolution]] 1.55Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TOP OCA]. For a <b>guided tour on the structure components</b> use [ | + | <table><tr><td colspan='2'>[[6top]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Porphyromonas_gingivalis_JCVI_SC001 Porphyromonas gingivalis JCVI SC001]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=6i9o 6i9o]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TOP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6TOP FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MLD:GLCNAC(BETA1-4)-MURNAC(1,6-ANHYDRO)-L-ALA-GAMMA-D-GLU-MESO-A2PM-D-ALA'>MLD</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6top FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6top OCA], [https://pdbe.org/6top PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6top RCSB], [https://www.ebi.ac.uk/pdbsum/6top PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6top ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/T2NEY1_PORGN T2NEY1_PORGN] | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Porphyromonas gingivalis, the major human pathogen associated to periodontal diseases, utilizes the Bacteroidetes-specific type IX secretion system (T9SS) to export virulence factors. PorE is a periplasmic multi-domain lipoprotein associated to the outer membrane that was recently identified as essential for T9SS function. Little is known on T9SS at the structural level, and in particular its interaction with peptidoglycan. This prompted us to carry out structural studies on PorE full length as well as on its four isolated domains. Here we report the crystal structure of the C-terminal OmpA_C-like putative peptidoglycan-binding domain at 1.55 A resolution. An electron density volume was identified in the protein cleft, making it possible to build a naturally-occurring peptidoglycan fragment. This result suggests that PorE interacts with peptidoglycan and that PorE could anchor T9SS to the cell wall. | ||
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| + | Crystal structure of Type IX secretion system PorE C-terminal domain from Porphyromonas gingivalis in complex with a peptidoglycan fragment.,Trinh NTT, Tran HQ, Van Dong Q, Cambillau C, Roussel A, Leone P Sci Rep. 2020 Apr 30;10(1):7384. doi: 10.1038/s41598-020-64115-z. PMID:32355178<ref>PMID:32355178</ref> | ||
| + | |||
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 6top" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| + | [[Category: Porphyromonas gingivalis JCVI SC001]] | ||
[[Category: Cambillau C]] | [[Category: Cambillau C]] | ||
[[Category: Leone P]] | [[Category: Leone P]] | ||
[[Category: Roussel A]] | [[Category: Roussel A]] | ||
[[Category: Trinh TN]] | [[Category: Trinh TN]] | ||
Current revision
Structure of the PorE C-terminal domain, a protein of T9SS from Porphyromonas gingivalis
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