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7btd

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==Crystal structure of Rheb Y35N mutant bound to GppNHp==
==Crystal structure of Rheb Y35N mutant bound to GppNHp==
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<StructureSection load='7btd' size='340' side='right'caption='[[7btd]]' scene=''>
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<StructureSection load='7btd' size='340' side='right'caption='[[7btd]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7BTD OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=7BTD FirstGlance]. <br>
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<table><tr><td colspan='2'>[[7btd]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7BTD OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=7BTD FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=7btd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7btd OCA], [http://pdbe.org/7btd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=7btd RCSB], [http://www.ebi.ac.uk/pdbsum/7btd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=7btd ProSAT]</span></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GNP:PHOSPHOAMINOPHOSPHONIC+ACID-GUANYLATE+ESTER'>GNP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">RHEB, RHEB2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=7btd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7btd OCA], [http://pdbe.org/7btd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=7btd RCSB], [http://www.ebi.ac.uk/pdbsum/7btd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=7btd ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/RHEB_HUMAN RHEB_HUMAN]] Stimulates the phosphorylation of S6K1 and EIF4EBP1 through activation of mTORC1 signaling. Activates the protein kinase activity of mTORC1. Has low intrinsic GTPase activity.<ref>PMID:12271141</ref> <ref>PMID:12869586</ref> <ref>PMID:15340059</ref> <ref>PMID:15854902</ref> <ref>PMID:16098514</ref> <ref>PMID:20381137</ref>
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==See Also==
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*[[GTP-binding protein 3D structures|GTP-binding protein 3D structures]]
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== References ==
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<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Ding J]]
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[[Category: Ding, J]]
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[[Category: Zhang C]]
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[[Category: Zhang, C]]
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[[Category: Zhang T]]
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[[Category: Zhang, T]]
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[[Category: Mtorc1]]
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[[Category: Rheb]]
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[[Category: Signaling protein]]
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[[Category: Small gtpase]]

Revision as of 07:03, 30 December 2020

Crystal structure of Rheb Y35N mutant bound to GppNHp

PDB ID 7btd

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