6oba

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<StructureSection load='6oba' size='340' side='right'caption='[[6oba]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
<StructureSection load='6oba' size='340' side='right'caption='[[6oba]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6oba]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6OBA OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6OBA FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6oba]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_virus_T4 Escherichia virus T4] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6OBA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6OBA FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene>, <scene name='pdbligand=JTZ:(2S)-1-[(1-METHYLETHYL)AMINO]-3-(2-PROP-2-EN-1-YLPHENOXY)PROPAN-2-OL'>JTZ</scene>, <scene name='pdbligand=M3J:6-bromo-N~2~-phenylquinazoline-2,4-diamine'>M3J</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.1&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ADRB2, ADRB2R, B2AR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene>, <scene name='pdbligand=JTZ:(2S)-1-[(1-METHYLETHYL)AMINO]-3-(2-PROP-2-EN-1-YLPHENOXY)PROPAN-2-OL'>JTZ</scene>, <scene name='pdbligand=M3J:6-bromo-N~2~-phenylquinazoline-2,4-diamine'>M3J</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6oba FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6oba OCA], [https://pdbe.org/6oba PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6oba RCSB], [https://www.ebi.ac.uk/pdbsum/6oba PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6oba ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6oba FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6oba OCA], [http://pdbe.org/6oba PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6oba RCSB], [http://www.ebi.ac.uk/pdbsum/6oba PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6oba ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/ADRB2_HUMAN ADRB2_HUMAN]] Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine.
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[https://www.uniprot.org/uniprot/D9IEF7_BPT4 D9IEF7_BPT4] [https://www.uniprot.org/uniprot/ADRB2_HUMAN ADRB2_HUMAN] Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
*[[Adrenergic receptor 3D structures|Adrenergic receptor 3D structures]]
*[[Adrenergic receptor 3D structures|Adrenergic receptor 3D structures]]
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*[[Lysozyme 3D structures|Lysozyme 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Escherichia virus T4]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Lysozyme]]
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[[Category: ClarK M]]
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[[Category: ClarK, M]]
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[[Category: Dengler D]]
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[[Category: Dengler, D]]
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[[Category: Gmeiner R]]
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[[Category: Gmeiner, R]]
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[[Category: Hirata K]]
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[[Category: Hirata, K]]
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[[Category: Hubner H]]
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[[Category: Hubner, H]]
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[[Category: Kaindl J]]
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[[Category: Kaindl, J]]
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[[Category: Kobilka BK]]
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[[Category: Kobilka, B K]]
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[[Category: Korczynska M]]
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[[Category: Korczynska, M]]
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[[Category: Liu X]]
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[[Category: Liu, X]]
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[[Category: Mahoney J]]
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[[Category: Mahoney, J]]
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[[Category: Matt RA]]
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[[Category: Matt, R A]]
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[[Category: Shoichet B]]
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[[Category: Shoichet, B]]
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[[Category: Stanek M]]
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[[Category: Stanek, M]]
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[[Category: Stobel A]]
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[[Category: Stobel, A]]
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[[Category: Sunahara R]]
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[[Category: Sunahara, R]]
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[[Category: Xu X]]
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[[Category: Xu, X]]
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[[Category: Allosteric modulator]]
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[[Category: G protein coupled receptor]]
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[[Category: Membrane protein]]
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[[Category: Signal transduction]]
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[[Category: Signaling protein]]
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Revision as of 07:07, 11 October 2023

The beta2 adrenergic receptor bound to a negative allosteric modulator

PDB ID 6oba

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