1bau
From Proteopedia
(New page: 200px<br /> <applet load="1bau" size="450" color="white" frame="true" align="right" spinBox="true" caption="1bau" /> '''NMR STRUCTURE OF THE DIMER INITIATION COMPL...) |
|||
| Line 1: | Line 1: | ||
| - | [[Image:1bau.gif|left|200px]]<br /> | + | [[Image:1bau.gif|left|200px]]<br /><applet load="1bau" size="350" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="1bau" size=" | + | |
caption="1bau" /> | caption="1bau" /> | ||
'''NMR STRUCTURE OF THE DIMER INITIATION COMPLEX OF HIV-1 GENOMIC RNA, MINIMIZED AVERAGE STRUCTURE'''<br /> | '''NMR STRUCTURE OF THE DIMER INITIATION COMPLEX OF HIV-1 GENOMIC RNA, MINIMIZED AVERAGE STRUCTURE'''<br /> | ||
==Overview== | ==Overview== | ||
| - | Retroviral genomes must dimerize to be fully infectious. Dimerization is | + | Retroviral genomes must dimerize to be fully infectious. Dimerization is directed by a unique RNA hairpin structure with a palindrome in its loop: hairpins of two strands first associate transiently through their loops, and then refold to a more stable, linear duplex. The structure of the initial, kissing-loop dimer from HIV-1, solved using 2D NMR, is bent and metastable, its interface being formed not only by standard basepairing between palindromes, but also by a distinctive pattern of interstrand stacking among bases at the stem-loop junctions. This creates mechanical distortions that partially melt both stems, which may facilitate spontaneous refolding of this RNA complex into linear form. |
==About this Structure== | ==About this Structure== | ||
| - | 1BAU is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http:// | + | 1BAU is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BAU OCA]. |
==Reference== | ==Reference== | ||
Structure of the dimer initiation complex of HIV-1 genomic RNA., Mujeeb A, Clever JL, Billeci TM, James TL, Parslow TG, Nat Struct Biol. 1998 Jun;5(6):432-6. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9628479 9628479] | Structure of the dimer initiation complex of HIV-1 genomic RNA., Mujeeb A, Clever JL, Billeci TM, James TL, Parslow TG, Nat Struct Biol. 1998 Jun;5(6):432-6. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9628479 9628479] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
| - | [[Category: Billeci, T | + | [[Category: Billeci, T M.]] |
| - | [[Category: Clever, J | + | [[Category: Clever, J L.]] |
| - | [[Category: James, T | + | [[Category: James, T L.]] |
[[Category: Mujeeb, A.]] | [[Category: Mujeeb, A.]] | ||
| - | [[Category: Parslow, T | + | [[Category: Parslow, T G.]] |
[[Category: dimerization]] | [[Category: dimerization]] | ||
[[Category: encapsidation]] | [[Category: encapsidation]] | ||
| Line 24: | Line 23: | ||
[[Category: rna]] | [[Category: rna]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 11:53:18 2008'' |
Revision as of 09:53, 21 February 2008
|
NMR STRUCTURE OF THE DIMER INITIATION COMPLEX OF HIV-1 GENOMIC RNA, MINIMIZED AVERAGE STRUCTURE
Overview
Retroviral genomes must dimerize to be fully infectious. Dimerization is directed by a unique RNA hairpin structure with a palindrome in its loop: hairpins of two strands first associate transiently through their loops, and then refold to a more stable, linear duplex. The structure of the initial, kissing-loop dimer from HIV-1, solved using 2D NMR, is bent and metastable, its interface being formed not only by standard basepairing between palindromes, but also by a distinctive pattern of interstrand stacking among bases at the stem-loop junctions. This creates mechanical distortions that partially melt both stems, which may facilitate spontaneous refolding of this RNA complex into linear form.
About this Structure
1BAU is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.
Reference
Structure of the dimer initiation complex of HIV-1 genomic RNA., Mujeeb A, Clever JL, Billeci TM, James TL, Parslow TG, Nat Struct Biol. 1998 Jun;5(6):432-6. PMID:9628479
Page seeded by OCA on Thu Feb 21 11:53:18 2008
