1bjj

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[[Image:1bjj.gif|left|200px]]
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{{STRUCTURE_1bjj| PDB=1bjj | SCENE= }}
{{STRUCTURE_1bjj| PDB=1bjj | SCENE= }}
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'''AGKISTRODOTOXIN, A PHOSPHOLIPASE A2-TYPE PRESYNAPTIC NEUROTOXIN FROM AGKISTRODON HALYS PALLAS'''
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===AGKISTRODOTOXIN, A PHOSPHOLIPASE A2-TYPE PRESYNAPTIC NEUROTOXIN FROM AGKISTRODON HALYS PALLAS===
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==Overview==
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The structure of agkistrodotoxin crystallized under basic conditions has been determined at 2.8 A resolution by the molecular-replacement technique and refined to a crystallographic R factor of 0.194 and a free R factor of 0.260 with good stereochemistry. The molecular packing in the crystal differs from other PLA(2)s. The six molecules in the asymmetric unit form three dimers linked by Ca(2+) ions in a near-perfect six-ligand octahedral coordinating system. Extensive intermolecular hydrophobic interactions occur at the interfacial recognition site of each neurotoxin molecule, which provides an insight into phospholipase A(2)-membrane interactions. This hydrophobic interaction-induced molecular association along the interfacial recognition site suggests a self-protection mechanism of agkistrodotoxin.
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(as it appears on PubMed at http://www.pubmed.gov), where 10666574 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10666574}}
==About this Structure==
==About this Structure==
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[[Category: Phospholipase a2]]
[[Category: Phospholipase a2]]
[[Category: Presynaptic neurotoxin]]
[[Category: Presynaptic neurotoxin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 11:35:50 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 19:15:59 2008''

Revision as of 16:16, 30 June 2008

Image:1bjj.png

Template:STRUCTURE 1bjj

AGKISTRODOTOXIN, A PHOSPHOLIPASE A2-TYPE PRESYNAPTIC NEUROTOXIN FROM AGKISTRODON HALYS PALLAS

Template:ABSTRACT PUBMED 10666574

About this Structure

1BJJ is a Single protein structure of sequence from Gloydius halys. Full crystallographic information is available from OCA.

Reference

Structure of agkistrodotoxin in an orthorhombic crystal form with six molecules per asymmetric unit., Tang L, Zhou YC, Lin ZJ, Acta Crystallogr D Biol Crystallogr. 1999 Dec;55(Pt 12):1986-96. PMID:10666574

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