We apologize for Proteopedia being slow to respond. For the past two years, a new implementation of Proteopedia has been being built. Soon, it will replace this 18-year old system. All existing content will be moved to the new system at a date that will be announced here.

5jv1

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (19:09, 20 September 2023) (edit) (undo)
 
Line 3: Line 3:
<StructureSection load='5jv1' size='340' side='right'caption='[[5jv1]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
<StructureSection load='5jv1' size='340' side='right'caption='[[5jv1]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[5jv1]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JV1 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5JV1 FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[5jv1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JV1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5JV1 FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=YL6:[(1R)-1-{[6-(3-CHLORO-4-METHYLPHENYL)THIENO[2,3-D]PYRIMIDIN-4-YL]AMINO}-2-(3-FLUOROPHENYL)ETHYL]PHOSPHONIC+ACID'>YL6</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
-
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5jv2|5jv2]], [[5jv0|5jv0]], [[5juz|5juz]]</td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=YL6:[(1R)-1-{[6-(3-CHLORO-4-METHYLPHENYL)THIENO[2,3-D]PYRIMIDIN-4-YL]AMINO}-2-(3-FLUOROPHENYL)ETHYL]PHOSPHONIC+ACID'>YL6</scene></td></tr>
-
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">FDPS, FPS, KIAA1293 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5jv1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jv1 OCA], [https://pdbe.org/5jv1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5jv1 RCSB], [https://www.ebi.ac.uk/pdbsum/5jv1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5jv1 ProSAT]</span></td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5jv1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jv1 OCA], [http://pdbe.org/5jv1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5jv1 RCSB], [http://www.ebi.ac.uk/pdbsum/5jv1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5jv1 ProSAT]</span></td></tr>
+
</table>
</table>
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/FPPS_HUMAN FPPS_HUMAN]] Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate.
+
[https://www.uniprot.org/uniprot/FPPS_HUMAN FPPS_HUMAN] Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 27: Line 26:
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Human]]
+
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
-
[[Category: Berghuis, A M]]
+
[[Category: Berghuis AM]]
-
[[Category: Leung, C Y]]
+
[[Category: Leung CY]]
-
[[Category: Park, J]]
+
[[Category: Park J]]
-
[[Category: Tsantrizos, Y S]]
+
[[Category: Tsantrizos YS]]
-
[[Category: Transferase]]
+
-
[[Category: Transferase-transferase inhibitor complex]]
+

Current revision

Crystal structure of human FPPS in complex with an allosteric inhibitor CL-08-066

PDB ID 5jv1

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/5jv1"
Personal tools