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5jxb

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Current revision (19:13, 20 September 2023) (edit) (undo)
 
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<StructureSection load='5jxb' size='340' side='right'caption='[[5jxb]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
<StructureSection load='5jxb' size='340' side='right'caption='[[5jxb]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5jxb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JXB OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5JXB FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5jxb]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JXB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5JXB FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">DLG4, PSD95 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5jxb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jxb OCA], [http://pdbe.org/5jxb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5jxb RCSB], [http://www.ebi.ac.uk/pdbsum/5jxb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5jxb ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5jxb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jxb OCA], [https://pdbe.org/5jxb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5jxb RCSB], [https://www.ebi.ac.uk/pdbsum/5jxb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5jxb ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/DLG4_HUMAN DLG4_HUMAN]] Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B (By similarity).
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[https://www.uniprot.org/uniprot/DLG4_HUMAN DLG4_HUMAN] Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B (By similarity).[https://www.uniprot.org/uniprot/J3QQ18_MOUSE J3QQ18_MOUSE]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5jxb" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5jxb" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Postsynaptic density protein 3D structures|Postsynaptic density protein 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Shang, Y]]
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[[Category: Mus musculus]]
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[[Category: Zhang, M]]
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[[Category: Shang Y]]
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[[Category: Cell adhesion]]
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[[Category: Zhang M]]
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[[Category: Extension]]
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[[Category: Pdz]]
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[[Category: Psd-95]]
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[[Category: Syngap]]
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Current revision

PSD-95 extended PDZ3 in complex with SynGAP PBM

PDB ID 5jxb

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