1bii
From Proteopedia
(New page: 200px<br /> <applet load="1bii" size="450" color="white" frame="true" align="right" spinBox="true" caption="1bii, resolution 2.4Å" /> '''THE CRYSTAL STRUCTUR...) |
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| - | [[Image:1bii.gif|left|200px]]<br /> | + | [[Image:1bii.gif|left|200px]]<br /><applet load="1bii" size="350" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="1bii" size=" | + | |
caption="1bii, resolution 2.4Å" /> | caption="1bii, resolution 2.4Å" /> | ||
'''THE CRYSTAL STRUCTURE OF H-2DD MHC CLASS I IN COMPLEX WITH THE HIV-1 DERIVED PEPTIDE P18-110'''<br /> | '''THE CRYSTAL STRUCTURE OF H-2DD MHC CLASS I IN COMPLEX WITH THE HIV-1 DERIVED PEPTIDE P18-110'''<br /> | ||
==Overview== | ==Overview== | ||
| - | The structure of H-2Dd complexed with the HIV-derived peptide P18-I10 | + | The structure of H-2Dd complexed with the HIV-derived peptide P18-I10 (RGPGRAFVTI) has been determined by X-ray crystallography at 2.4 A resolution. This MHC class I molecule has an unusual binding motif with four anchor residues in the peptide (G2, P3, R/K/H5, and I/L/F9 or 10). The cleft architecture of H-2Dd includes a deep narrow passage accomodating the N-terminal part of the peptide, explaining the obligatory G2P3 anchor motif. Toward the C-terminal half of the peptide, p5R to p8V form a type I' reverse turn; residues p6A to p9T, and in particular p7F, are readily exposed. The structure is discussed in relation to functional data available for T cell and natural killer cell recognition of the H-2Dd molecule. |
==About this Structure== | ==About this Structure== | ||
| - | 1BII is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http:// | + | 1BII is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BII OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Protein complex]] | [[Category: Protein complex]] | ||
[[Category: Achour, A.]] | [[Category: Achour, A.]] | ||
| - | [[Category: Harris, R | + | [[Category: Harris, R A.]] |
[[Category: Karre, K.]] | [[Category: Karre, K.]] | ||
[[Category: Lindqvist, Y.]] | [[Category: Lindqvist, Y.]] | ||
[[Category: Persson, K.]] | [[Category: Persson, K.]] | ||
[[Category: Schneider, G.]] | [[Category: Schneider, G.]] | ||
| - | [[Category: Sentman, C | + | [[Category: Sentman, C L.]] |
[[Category: Sundback, J.]] | [[Category: Sundback, J.]] | ||
[[Category: complex (mhc i/peptide)]] | [[Category: complex (mhc i/peptide)]] | ||
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[[Category: transmembrane]] | [[Category: transmembrane]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 11:55:38 2008'' |
Revision as of 09:55, 21 February 2008
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THE CRYSTAL STRUCTURE OF H-2DD MHC CLASS I IN COMPLEX WITH THE HIV-1 DERIVED PEPTIDE P18-110
Overview
The structure of H-2Dd complexed with the HIV-derived peptide P18-I10 (RGPGRAFVTI) has been determined by X-ray crystallography at 2.4 A resolution. This MHC class I molecule has an unusual binding motif with four anchor residues in the peptide (G2, P3, R/K/H5, and I/L/F9 or 10). The cleft architecture of H-2Dd includes a deep narrow passage accomodating the N-terminal part of the peptide, explaining the obligatory G2P3 anchor motif. Toward the C-terminal half of the peptide, p5R to p8V form a type I' reverse turn; residues p6A to p9T, and in particular p7F, are readily exposed. The structure is discussed in relation to functional data available for T cell and natural killer cell recognition of the H-2Dd molecule.
About this Structure
1BII is a Protein complex structure of sequences from Mus musculus. Full crystallographic information is available from OCA.
Reference
The crystal structure of H-2Dd MHC class I complexed with the HIV-1-derived peptide P18-I10 at 2.4 A resolution: implications for T cell and NK cell recognition., Achour A, Persson K, Harris RA, Sundback J, Sentman CL, Lindqvist Y, Schneider G, Karre K, Immunity. 1998 Aug;9(2):199-208. PMID:9729040
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