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2uui

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(New page: 200px<br /> <applet load="2uui" size="450" color="white" frame="true" align="right" spinBox="true" caption="2uui, resolution 2.00&Aring;" /> '''CRYSTAL STRUCTURE O...)
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==About this Structure==
==About this Structure==
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2UUI is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with NI, SO4, LMT and PLM as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.4.1.20 4.4.1.20]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2UUI OCA]].
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2UUI is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with NI, SO4, LMT and PLM as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/Leukotriene-C(4)_synthase Leukotriene-C(4) synthase]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.4.1.20 4.4.1.20]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2UUI OCA]].
==Reference==
==Reference==
Structural basis for synthesis of inflammatory mediators by human leukotriene C4 synthase., Molina DM, Wetterholm A, Kohl A, McCarthy AA, Niegowski D, Ohlson E, Hammarberg T, Eshaghi S, Haeggstrom JZ, Nordlund P, Nature. 2007 Aug 2;448(7153):613-6. Epub 2007 Jul 15. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17632546 17632546]
Structural basis for synthesis of inflammatory mediators by human leukotriene C4 synthase., Molina DM, Wetterholm A, Kohl A, McCarthy AA, Niegowski D, Ohlson E, Hammarberg T, Eshaghi S, Haeggstrom JZ, Nordlund P, Nature. 2007 Aug 2;448(7153):613-6. Epub 2007 Jul 15. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17632546 17632546]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Leukotriene-C(4) synthase]]
[[Category: Single protein]]
[[Category: Single protein]]
[[Category: Eshaghi, S.]]
[[Category: Eshaghi, S.]]
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[[Category: trimer]]
[[Category: trimer]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Oct 29 17:51:13 2007''
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 11:24:43 2007''

Revision as of 09:20, 30 October 2007

Image:2uui.gif

2uui, resolution 2.00Å

Drag the structure with the mouse to rotate

CRYSTAL STRUCTURE OF HUMAN LEUKOTRIENE C4 SYNTHASE

Overview

Cysteinyl leukotrienes are key mediators in inflammation and have an, important role in acute and chronic inflammatory diseases of the, cardiovascular and respiratory systems, in particular bronchial asthma. In, the biosynthesis of cysteinyl leukotrienes, conversion of arachidonic acid, forms the unstable epoxide leukotriene A4 (LTA4). This intermediate is, conjugated with glutathione (GSH) to produce leukotriene C4 (LTC4) in a, reaction catalysed by LTC4 synthase: this reaction is the key step in, cysteinyl leukotriene formation. Here we present the crystal structure of, the human LTC4 synthase in its apo and GSH-complexed forms to 2.00 and, 2.15 A resolution, respectively. The structure reveals a homotrimer, where, each monomer is composed of four transmembrane segments. The structure ... [(full description)]

About this Structure

2UUI is a [Single protein] structure of sequence from [Homo sapiens] with NI, SO4, LMT and PLM as [ligands]. Active as [Leukotriene-C(4) synthase], with EC number [4.4.1.20]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].

Reference

Structural basis for synthesis of inflammatory mediators by human leukotriene C4 synthase., Molina DM, Wetterholm A, Kohl A, McCarthy AA, Niegowski D, Ohlson E, Hammarberg T, Eshaghi S, Haeggstrom JZ, Nordlund P, Nature. 2007 Aug 2;448(7153):613-6. Epub 2007 Jul 15. PMID:17632546

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