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1bk7

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[[Image:1bk7.jpg|left|200px]]
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{{STRUCTURE_1bk7| PDB=1bk7 | SCENE= }}
{{STRUCTURE_1bk7| PDB=1bk7 | SCENE= }}
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'''RIBONUCLEASE MC1 FROM THE SEEDS OF BITTER GOURD'''
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===RIBONUCLEASE MC1 FROM THE SEEDS OF BITTER GOURD===
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==Overview==
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The ribonuclease MC1 (RNase MC1) from seeds of bitter gourd (Momordica charantia) consists of 190 amino acid residues with four disulfide bridges and belongs to the RNase T(2) family, including fungal RNases typified by RNase Rh from Rhizopus niveus and RNase T(2) from Aspergillus oryzae. The crystal structure of RNase MC1 has been determined at 1.75 A resolution with an R-factor of 19.7% using the single isomorphous replacement method. RNase MC1 structurally belongs to the (alpha+beta) class of proteins, having ten helices (six alpha-helices and four 3(10)-helices) and eight beta-strands. When the structures of RNase MC1 and RNase Rh are superposed, the close agreement between the alpha-carbon positions for the total structure is obvious: the root mean square deviations calculated only for structurally related 151 alpha-carbon atoms of RNase MC1 and RNase Rh molecules was 1.76 A. Furthermore, the conformation of the catalytic residues His-46, Glu-105, and His-109 in RNase Rh can be easily superposed with that of the possible catalytic residues His-34, Glu-84, and His-88 in RNase MC1. This observation strongly indicates that RNase MC1 from a plant origin catalyzes RNA degradation in a similar manner as fungal RNases.
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(as it appears on PubMed at http://www.pubmed.gov), where 10446375 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10446375}}
==About this Structure==
==About this Structure==
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[[Category: Nakagawa, A.]]
[[Category: Nakagawa, A.]]
[[Category: Tanaka, I.]]
[[Category: Tanaka, I.]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 11:37:23 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 19:17:45 2008''

Revision as of 16:17, 30 June 2008

Image:1bk7.png

Template:STRUCTURE 1bk7

RIBONUCLEASE MC1 FROM THE SEEDS OF BITTER GOURD

Template:ABSTRACT PUBMED 10446375

About this Structure

1BK7 is a Single protein structure of sequence from Momordica charantia. Full crystallographic information is available from OCA.

Reference

Crystal structure of a ribonuclease from the seeds of bitter gourd (Momordica charantia) at 1.75 A resolution., Nakagawa A, Tanaka I, Sakai R, Nakashima T, Funatsu G, Kimura M, Biochim Biophys Acta. 1999 Aug 17;1433(1-2):253-60. PMID:10446375

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