1bkd

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[[Image:1bkd.gif|left|200px]]
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{{Seed}}
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[[Image:1bkd.png|left|200px]]
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{{STRUCTURE_1bkd| PDB=1bkd | SCENE= }}
{{STRUCTURE_1bkd| PDB=1bkd | SCENE= }}
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'''COMPLEX OF HUMAN H-RAS WITH HUMAN SOS-1'''
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===COMPLEX OF HUMAN H-RAS WITH HUMAN SOS-1===
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==Overview==
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The crystal structure of human H-Ras complexed with the Ras guanine-nucleotide-exchange-factor region of the Son of sevenless (Sos) protein has been determined at 2.8 A resolution. The normally tight interaction of nucleotides with Ras is disrupted by Sos in two ways. First, the insertion into Ras of an alpha-helix from Sos results in the displacement of the Switch 1 region of Ras, opening up the nucleotide-binding site. Second, side chains presented by this helix and by a distorted conformation of the Switch 2 region of Ras alter the chemical environment of the binding site for the phosphate groups of the nucleotide and the associated magnesium ion, so that their binding is no longer favoured. Sos does not impede the binding sites for the base and the ribose of GTP or GDP, so the Ras-Sos complex adopts a structure that allows nucleotide release and rebinding.
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The line below this paragraph, {{ABSTRACT_PUBMED_9690470}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 9690470 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9690470}}
==About this Structure==
==About this Structure==
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[[Category: Exchange factor]]
[[Category: Exchange factor]]
[[Category: Small gtpase]]
[[Category: Small gtpase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 11:37:47 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 19:18:17 2008''

Revision as of 16:18, 30 June 2008

Image:1bkd.png

Template:STRUCTURE 1bkd

COMPLEX OF HUMAN H-RAS WITH HUMAN SOS-1

Template:ABSTRACT PUBMED 9690470

About this Structure

1BKD is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The structural basis of the activation of Ras by Sos., Boriack-Sjodin PA, Margarit SM, Bar-Sagi D, Kuriyan J, Nature. 1998 Jul 23;394(6691):337-43. PMID:9690470

Page seeded by OCA on Mon Jun 30 19:18:17 2008

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