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1bkt

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{{STRUCTURE_1bkt| PDB=1bkt | SCENE= }}
{{STRUCTURE_1bkt| PDB=1bkt | SCENE= }}
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'''BMKTX TOXIN FROM SCORPION BUTHUS MARTENSII KARSCH, NMR, 25 STRUCTURES'''
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===BMKTX TOXIN FROM SCORPION BUTHUS MARTENSII KARSCH, NMR, 25 STRUCTURES===
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==Overview==
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BmKTX is a toxin recently purified from the venom of Buthus Martensi, which belongs to the kaliotoxin family. We have determined its solution structure by use of conventional two-dimensional NMR techniques followed by distance-geometry and energy minimization. The calculated structure is composed of a short alpha-helix (residues 14 to 20) connected by a tight turn to a two-stranded antiparallel beta-sheet (sequences 25-27 and 32-34). The beta-turn connecting these strands belongs to type I. The N-terminal segment (sequence 1 to 8) runs parallel to the beta-sheet although it cannot be considered as a third strand. Comparison of the conformation of BmKTX and toxins of the kaliotoxin family clearly demonstrates that they are highly related. Therefore, analysis of the residues belonging to the interacting surface of those toxins allows us to propose a functional map of BmKTX slightly different from the one of KTX and AgTX2, which may explain the variations in affinities of these toxins towards the Kv1.3 channels.
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{{ABSTRACT_PUBMED_10651040}}
==About this Structure==
==About this Structure==
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1BKT is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mesobuthus_martensii Mesobuthus martensii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BKT OCA].
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1BKT is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mesobuthus_martensii Mesobuthus martensii]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BKT OCA].
==Reference==
==Reference==
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[[Category: Structure]]
[[Category: Structure]]
[[Category: Voltage gated potassium channel]]
[[Category: Voltage gated potassium channel]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 11:38:31 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 19:19:14 2008''

Revision as of 16:19, 30 June 2008

Image:1bkt.png

Template:STRUCTURE 1bkt

BMKTX TOXIN FROM SCORPION BUTHUS MARTENSII KARSCH, NMR, 25 STRUCTURES

Template:ABSTRACT PUBMED 10651040

About this Structure

1BKT is a Single protein structure of sequence from Mesobuthus martensii. Full experimental information is available from OCA.

Reference

Solution structure of BmKTX, a K+ blocker toxin from the Chinese scorpion Buthus Martensi., Renisio JG, Romi-Lebrun R, Blanc E, Bornet O, Nakajima T, Darbon H, Proteins. 2000 Jan 1;38(1):70-8. PMID:10651040

Page seeded by OCA on Mon Jun 30 19:19:14 2008

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