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1bl5

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[[Image:1bl5.gif|left|200px]]
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{{Seed}}
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[[Image:1bl5.png|left|200px]]
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{{STRUCTURE_1bl5| PDB=1bl5 | SCENE= }}
{{STRUCTURE_1bl5| PDB=1bl5 | SCENE= }}
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'''ISOCITRATE DEHYDROGENASE FROM E. COLI SINGLE TURNOVER LAUE STRUCTURE OF RATE-LIMITED PRODUCT COMPLEX, 10 MSEC TIME RESOLUTION'''
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===ISOCITRATE DEHYDROGENASE FROM E. COLI SINGLE TURNOVER LAUE STRUCTURE OF RATE-LIMITED PRODUCT COMPLEX, 10 MSEC TIME RESOLUTION===
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==Overview==
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The structure of a rate-limited product complex formed during a single initial round of turnover by isocitrate dehydrogenase has been determined. Photolytic liberation of either caged substrate or caged cofactor and Laue X-ray data collection were used to visualize the complex, which has a minimum half-life of approximately 10 milliseconds. The experiment was conducted with three different photoreactive compounds, each possessing a unique mechanism leading to the formation of the enzyme-substrate (ES) complex. Photoreaction efficiency and subsequent substrate affinities and binding rates in the crystal are critical parameters for these experiments. The structure suggests that CO2 dissociation is a rapid event that may help drive product formation, and that small conformational changes may contribute to slow product release.
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The line below this paragraph, {{ABSTRACT_PUBMED_9783749}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 9783749 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9783749}}
==About this Structure==
==About this Structure==
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[[Category: Oxidoreductase]]
[[Category: Oxidoreductase]]
[[Category: Phosphorylation]]
[[Category: Phosphorylation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 11:39:18 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 19:20:01 2008''

Revision as of 16:20, 30 June 2008

Image:1bl5.png

Template:STRUCTURE 1bl5

ISOCITRATE DEHYDROGENASE FROM E. COLI SINGLE TURNOVER LAUE STRUCTURE OF RATE-LIMITED PRODUCT COMPLEX, 10 MSEC TIME RESOLUTION

Template:ABSTRACT PUBMED 9783749

About this Structure

1BL5 is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Millisecond Laue structures of an enzyme-product complex using photocaged substrate analogs., Stoddard BL, Cohen BE, Brubaker M, Mesecar AD, Koshland DE Jr, Nat Struct Biol. 1998 Oct;5(10):891-7. PMID:9783749

Page seeded by OCA on Mon Jun 30 19:20:01 2008

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