1bmo

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{{STRUCTURE_1bmo| PDB=1bmo | SCENE= }}
{{STRUCTURE_1bmo| PDB=1bmo | SCENE= }}
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'''BM-40, FS/EC DOMAIN PAIR'''
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===BM-40, FS/EC DOMAIN PAIR===
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==Overview==
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BM-40 (also known as SPARC or osteonectin) is an anti-adhesive secreted glycoprotein involved in tissue remodelling. Apart from an acidic N-terminal segment, BM-40 consists of a follistatin-like (FS) domain and an EF-hand calcium-binding (EC) domain. Here we report the crystal structure at 3.1 A resolution of the FS-EC domain pair of human BM-40. The two distinct domains interact through a small interface that involves the EF-hand pair of the EC domain. Residues implicated in cell binding, inhibition of cell spreading and disassembly of focal adhesions cluster on one face of BM-40, opposite the binding epitope for collagens and the N-linked carbohydrate. The elongated FS domain is structurally related to serine protease inhibitors of the Kazal family. Notable differences are an insertion into the inhibitory loop in BM-40 and a protruding N-terminal beta-hairpin with striking similarities to epidermal growth factor. This hairpin is likely to act as a rigid spacer in proteins containing tandemly repeated FS domains, such as follistatin and agrin, and forms the heparin-binding site in follistatin.
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(as it appears on PubMed at http://www.pubmed.gov), where 9233787 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9233787}}
==About this Structure==
==About this Structure==
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[[Category: Extracellular module]]
[[Category: Extracellular module]]
[[Category: Glycoprotein]]
[[Category: Glycoprotein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 11:42:22 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 19:23:28 2008''

Revision as of 16:23, 30 June 2008

Image:1bmo.png

Template:STRUCTURE 1bmo

BM-40, FS/EC DOMAIN PAIR

Template:ABSTRACT PUBMED 9233787

About this Structure

1BMO is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of a pair of follistatin-like and EF-hand calcium-binding domains in BM-40., Hohenester E, Maurer P, Timpl R, EMBO J. 1997 Jul 1;16(13):3778-86. PMID:9233787

Page seeded by OCA on Mon Jun 30 19:23:28 2008

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