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1bmw

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[[Image:1bmw.gif|left|200px]]
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{{STRUCTURE_1bmw| PDB=1bmw | SCENE= }}
{{STRUCTURE_1bmw| PDB=1bmw | SCENE= }}
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'''A FIBRONECTIN TYPE III FOLD IN PLANT ALLERGENS: THE SOLUTION STRUCTURE OF PHL PII FROM TIMOTHY GRASS POLLEN, NMR, 38 STRUCTURES'''
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===A FIBRONECTIN TYPE III FOLD IN PLANT ALLERGENS: THE SOLUTION STRUCTURE OF PHL PII FROM TIMOTHY GRASS POLLEN, NMR, 38 STRUCTURES===
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==Overview==
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BACKGROUND: Grass pollen allergens are the most important and widespread elicitors of pollen allergy. One of the major plant allergens which millions of people worldwide are sensitized to is Phl p 2, a small protein from timothy grass pollen. Phl p 2 is representative of the large family of cross-reacting plant allergens classified as group 2/3. Recombinant Phl p 2 has been demonstrated by immunological cross-reactivity studies to be immunologically equivalent to the natural protein. RESULTS: We have solved the solution structure of recombinant Phl p 2 by means of nuclear magnetic resonance techniques. The three-dimensional structure of Phl p 2 consists of an all-beta fold with nine antiparallel beta strands that form a beta sandwich. The topology is that of an immunoglobulin-like fold with the addition of a C-terminal strand, as found in the C2 domain superfamily. Lack of functional and sequence similarity with these two families, however, suggests an independent evolution of Phl p 2 and other homologous plant allergens. CONCLUSIONS: Because of the high homology with other plant allergens of groups 1 and 2/3, the structure of Phl p 2 can be used to rationalize some of the immunological properties of the whole family. On the basis of the structure, we suggest possible sites of interaction with IgE antibodies. Knowledge of the Phl p 2 structure may assist the rational structure-based design of synthetic vaccines against grass pollen allergy.
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(as it appears on PubMed at http://www.pubmed.gov), where 10467147 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10467147}}
==About this Structure==
==About this Structure==
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1BMW is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Phleum_pratense Phleum pratense]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BMW OCA].
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1BMW is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Phleum_pratense Phleum pratense]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BMW OCA].
==Reference==
==Reference==
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[[Category: Immunology]]
[[Category: Immunology]]
[[Category: Nmr]]
[[Category: Nmr]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 11:42:53 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 19:24:00 2008''

Revision as of 16:24, 30 June 2008

Image:1bmw.png

Template:STRUCTURE 1bmw

A FIBRONECTIN TYPE III FOLD IN PLANT ALLERGENS: THE SOLUTION STRUCTURE OF PHL PII FROM TIMOTHY GRASS POLLEN, NMR, 38 STRUCTURES

Template:ABSTRACT PUBMED 10467147

About this Structure

1BMW is a Single protein structure of sequence from Phleum pratense. Full experimental information is available from OCA.

Reference

An immunoglobulin-like fold in a major plant allergen: the solution structure of Phl p 2 from timothy grass pollen., De Marino S, Morelli MA, Fraternali F, Tamborini E, Musco G, Vrtala S, Dolecek C, Arosio P, Valenta R, Pastore A, Structure. 1999 Aug 15;7(8):943-52. PMID:10467147

Page seeded by OCA on Mon Jun 30 19:24:00 2008

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