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1bnl

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[[Image:1bnl.gif|left|200px]]
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{{STRUCTURE_1bnl| PDB=1bnl | SCENE= }}
{{STRUCTURE_1bnl| PDB=1bnl | SCENE= }}
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'''ZINC DEPENDENT DIMERS OBSERVED IN CRYSTALS OF HUMAN ENDOSTATIN'''
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===ZINC DEPENDENT DIMERS OBSERVED IN CRYSTALS OF HUMAN ENDOSTATIN===
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==Overview==
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The crystal structure of human endostatin reveals a zinc-binding site. Atomic absorption spectroscopy indicates that zinc is a constituent of both human and murine endostatin in solution. The human endostatin zinc site is formed by three histidines at the N terminus, residues 1, 3, and, 11, and an aspartic acid at residue 76. The N-terminal loop ordered around the zinc makes a dimeric contact in human endostatin crystals. The location of the zinc site at the amino terminus, immediately adjacent to the precursor cleavage site, suggests the possibility that the zinc may be involved in activation of the antiangiogenic activity following cleavage from the inactive collagen XVIII precursor or in the cleavage process itself.
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(as it appears on PubMed at http://www.pubmed.gov), where 9724722 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9724722}}
==About this Structure==
==About this Structure==
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[[Category: Extracellular matrix]]
[[Category: Extracellular matrix]]
[[Category: Zinc]]
[[Category: Zinc]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 11:44:14 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 19:25:31 2008''

Revision as of 16:25, 30 June 2008

Image:1bnl.png

Template:STRUCTURE 1bnl

ZINC DEPENDENT DIMERS OBSERVED IN CRYSTALS OF HUMAN ENDOSTATIN

Template:ABSTRACT PUBMED 9724722

About this Structure

1BNL is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Zinc-dependent dimers observed in crystals of human endostatin., Ding YH, Javaherian K, Lo KM, Chopra R, Boehm T, Lanciotti J, Harris BA, Li Y, Shapiro R, Hohenester E, Timpl R, Folkman J, Wiley DC, Proc Natl Acad Sci U S A. 1998 Sep 1;95(18):10443-8. PMID:9724722

Page seeded by OCA on Mon Jun 30 19:25:31 2008

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