1bo1

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[[Image:1bo1.jpg|left|200px]]
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{{STRUCTURE_1bo1| PDB=1bo1 | SCENE= }}
{{STRUCTURE_1bo1| PDB=1bo1 | SCENE= }}
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'''PHOSPHATIDYLINOSITOL PHOSPHATE KINASE TYPE II BETA'''
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===PHOSPHATIDYLINOSITOL PHOSPHATE KINASE TYPE II BETA===
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==Overview==
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Phosphoinositide kinases play central roles in signal transduction by phosphorylating the inositol ring at specific positions. The structure of one such enzyme, type IIbeta phosphatidylinositol phosphate kinase, reveals a protein kinase ATP-binding core and demonstrates that all phosphoinositide kinases belong to one superfamily. The enzyme is a disc-shaped homodimer with a 33 x 48 A basic flat face that suggests an electrostatic mechanism for plasma membrane targeting. Conserved basic residues form a putative phosphatidylinositol phosphate specificity site. The substrate-binding site is open on one side, consistent with dual specificity for phosphatidylinositol 3- and 5-phosphates. A modeled complex with membrane-bound substrate and ATP shows how a phosphoinositide kinase can phosphorylate its substrate in situ at the membrane interface.
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(as it appears on PubMed at http://www.pubmed.gov), where 9753329 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9753329}}
==About this Structure==
==About this Structure==
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[[Category: Rao, V D.]]
[[Category: Rao, V D.]]
[[Category: Lipid signaling]]
[[Category: Lipid signaling]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 11:45:11 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 19:26:38 2008''

Revision as of 16:26, 30 June 2008

Image:1bo1.png

Template:STRUCTURE 1bo1

PHOSPHATIDYLINOSITOL PHOSPHATE KINASE TYPE II BETA

Template:ABSTRACT PUBMED 9753329

About this Structure

1BO1 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of type IIbeta phosphatidylinositol phosphate kinase: a protein kinase fold flattened for interfacial phosphorylation., Rao VD, Misra S, Boronenkov IV, Anderson RA, Hurley JH, Cell. 1998 Sep 18;94(6):829-39. PMID:9753329

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