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1bos

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[[Image:1bos.gif|left|200px]]
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{{STRUCTURE_1bos| PDB=1bos | SCENE= }}
{{STRUCTURE_1bos| PDB=1bos | SCENE= }}
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'''SHIGA-LIKE TOXIN COMPLEXED WITH ITS RECEPTOR'''
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===SHIGA-LIKE TOXIN COMPLEXED WITH ITS RECEPTOR===
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==Overview==
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Shiga-like toxin I (SLT-I) is a virulence factor of Escherichia coli strains that cause disease in humans. Like other members of the Shiga toxin family, it consists of an enzymatic (A) subunit and five copies of a binding subunit (the B-pentamer). The B-pentamer binds to a specific glycolipid, globotriaosylceramide (Gb3), on the surface of target cells and thereby plays a crucial role in the entry of the toxin. Here we present the crystal structure at 2.8 A resolution of the SLT-I B-pentamer complexed with an analogue of the Gb3 trisaccharide. The structure reveals a surprising density of binding sites, with three trisaccharide molecules bound to each B-subunit monomer of 69 residues. All 15 trisaccharides bind to one side of the B-pentamer, providing further evidence that this side faces the cell membrane. The structural model is consistent with data from site-directed mutagenesis and binding of carbohydrate analogues, and allows the rational design of therapeutic Gb3 analogues that block the attachment of toxin to cells.
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The line below this paragraph, {{ABSTRACT_PUBMED_9485303}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 9485303 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9485303}}
==About this Structure==
==About this Structure==
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[[Category: Receptor binding]]
[[Category: Receptor binding]]
[[Category: Toxin]]
[[Category: Toxin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 11:46:38 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 19:28:31 2008''

Revision as of 16:28, 30 June 2008

Image:1bos.png

Template:STRUCTURE 1bos

SHIGA-LIKE TOXIN COMPLEXED WITH ITS RECEPTOR

Template:ABSTRACT PUBMED 9485303

About this Structure

1BOS is a Single protein structure of sequence from Bacteriophage h30, bacteriophage h19b. Full crystallographic information is available from OCA.

Reference

Structure of the shiga-like toxin I B-pentamer complexed with an analogue of its receptor Gb3., Ling H, Boodhoo A, Hazes B, Cummings MD, Armstrong GD, Brunton JL, Read RJ, Biochemistry. 1998 Feb 17;37(7):1777-88. PMID:9485303

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