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1bp3

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{{STRUCTURE_1bp3| PDB=1bp3 | SCENE= }}
{{STRUCTURE_1bp3| PDB=1bp3 | SCENE= }}
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'''THE XRAY STRUCTURE OF A GROWTH HORMONE-PROLACTIN RECEPTOR COMPLEX'''
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===THE XRAY STRUCTURE OF A GROWTH HORMONE-PROLACTIN RECEPTOR COMPLEX===
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==Overview==
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The human pituitary hormones, growth hormone (hGH) and prolactin (hPRL), regulate a large variety of physiological processes, among which are growth and differentiation of muscle, bone and cartilage cells, and lactation. These activities are initiated by hormone-receptor binding. The hGH and hPRL receptors (hGHR and hPRLR, respectively) are single-pass transmembrane receptors from class 1 of the haematopoietic receptor superfamily. This classification is based on sequence similarity in their extracellular domains, notably a highly conserved pentapeptide, the so-called 'WSXWS box', the function of which is controversial. All ligands in class 1 activate their respective receptors by clustering mechanisms. In the case of hGH, activation involves receptor homodimerization in a sequential process: the active ternary complex containing one ligand and two receptor molecules is formed by association of a receptor molecule to an intermediate 1:1 complex. hPRL does not bind to the hGH receptor, but hGH binds to both the hGHR and hPRLR, and mutagenesis studies have shown that the receptor-binding sites on hGH overlap. We present here the crystal structure of the 1:1 complex of hGH bound to the extracellular domain of the hPRLR. Comparisons with the hGH-hGHR complex reveal how hGH can bind to the two distinctly different receptor binding surfaces.
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The line below this paragraph, {{ABSTRACT_PUBMED_7984244}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 7984244 is the PubMed ID number.
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{{ABSTRACT_PUBMED_7984244}}
==About this Structure==
==About this Structure==
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[[Category: Hormone/growth factor]]
[[Category: Hormone/growth factor]]
[[Category: Receptor]]
[[Category: Receptor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 11:47:27 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 19:29:05 2008''

Revision as of 16:29, 30 June 2008

Image:1bp3.png

Template:STRUCTURE 1bp3

THE XRAY STRUCTURE OF A GROWTH HORMONE-PROLACTIN RECEPTOR COMPLEX

Template:ABSTRACT PUBMED 7984244

About this Structure

1BP3 is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The X-ray structure of a growth hormone-prolactin receptor complex., Somers W, Ultsch M, De Vos AM, Kossiakoff AA, Nature. 1994 Dec 1;372(6505):478-81. PMID:7984244

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