1bql

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{{STRUCTURE_1bql| PDB=1bql | SCENE= }}
{{STRUCTURE_1bql| PDB=1bql | SCENE= }}
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'''STRUCTURE OF AN ANTI-HEL FAB FRAGMENT COMPLEXED WITH BOBWHITE QUAIL LYSOZYME'''
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===STRUCTURE OF AN ANTI-HEL FAB FRAGMENT COMPLEXED WITH BOBWHITE QUAIL LYSOZYME===
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==Overview==
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The HyHEL-5 antibody has more than a thousandfold lower affinity for bobwhite quail lysozyme (BWQL) than for hen egg-white lysozyme (HEL). Four sequence differences exist between BWQL and HEL, of which only one is involved in the interface with the Fab. The structure of bobwhite quail lysozyme has been determined in the uncomplexed state in two different crystal forms and in the complexed state with HyHEL-5, an antihen egg-white lysozyme Fab. Similar backbone conformations are observed in the three molecules of the two crystal forms of uncomplexed BWQL, although they show considerable variability in side-chain conformation. A relatively mobile segment in uncomplexed BWQL is observed to be part of the HyHEL-5 epitope. No major backbone conformational differences are observed in the lysozyme upon complex formation, but side-chain conformational differences are seen in surface residues that are involved in the interface with the antibody. The hydrogen bonding in the interface between BWQL and HyHEL-5 is similar to that in previously determined lysozyme-HyHEL-5 complexes.
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(as it appears on PubMed at http://www.pubmed.gov), where 8880929 is the PubMed ID number.
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{{ABSTRACT_PUBMED_8880929}}
==About this Structure==
==About this Structure==
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[[Category: Chacko, S.]]
[[Category: Chacko, S.]]
[[Category: Davies, D R.]]
[[Category: Davies, D R.]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 19:32:41 2008''

Revision as of 16:32, 30 June 2008

Image:1bql.png

Template:STRUCTURE 1bql

STRUCTURE OF AN ANTI-HEL FAB FRAGMENT COMPLEXED WITH BOBWHITE QUAIL LYSOZYME

Template:ABSTRACT PUBMED 8880929

About this Structure

1BQL is a Protein complex structure of sequences from Colinus virginianus and Mus musculus. Full crystallographic information is available from OCA.

Reference

Refined structures of bobwhite quail lysozyme uncomplexed and complexed with the HyHEL-5 Fab fragment., Chacko S, Silverton EW, Smith-Gill SJ, Davies DR, Shick KA, Xavier KA, Willson RC, Jeffrey PD, Chang CY, Sieker LC, Sheriff S, Proteins. 1996 Sep;26(1):55-65. PMID:8880929

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