1bqt

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[[Image:1bqt.gif|left|200px]]
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{{Seed}}
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[[Image:1bqt.png|left|200px]]
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{{STRUCTURE_1bqt| PDB=1bqt | SCENE= }}
{{STRUCTURE_1bqt| PDB=1bqt | SCENE= }}
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'''THREE-DIMENSIONAL STRUCTURE OF HUMAN INSULIN-LIKE GROWTH FACTOR-I (IGF-I) DETERMINED BY 1H-NMR AND DISTANCE GEOMETRY, 6 STRUCTURES'''
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===THREE-DIMENSIONAL STRUCTURE OF HUMAN INSULIN-LIKE GROWTH FACTOR-I (IGF-I) DETERMINED BY 1H-NMR AND DISTANCE GEOMETRY, 6 STRUCTURES===
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==Overview==
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The three-dimensional structure of human insulin-like growth factor-I has been determined through a combination of NMR measurements and distance geometry calculations. A total of 320 interatomic distance constraints, including 12 related to the disulfide bridges, were used in these calculations. The resulting structure is characterized by the presence of three helical rods corresponding to the sequence regions, Ala8-Cys18, Gly42-Cys48 and Leu54-Cys61. Furthermore, a turn structure and an extended structure exist in the Gly19-Gly22 and Phe23-Asn26 regions, respectively. Neglecting the N- and C-termini, with their expectedly high degree of mobility as well as a fluctuating C-domain, the r.m.s.d. value is 1.9 A for backbone atoms. Those of the three alpha-helical regions are 1.0, 0.9 and 0.8 A, respectively, 1.8 A being that for the total backbone atoms participating in the formation of these three helices, showing the good convergence of their spatial arrangements. The overall structure obtained here shows that the human IGF-I molecule folds into a spatial structure very similar to that of insulin in an aqueous solution.
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The line below this paragraph, {{ABSTRACT_PUBMED_8391516}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 8391516 is the PubMed ID number.
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{{ABSTRACT_PUBMED_8391516}}
==About this Structure==
==About this Structure==
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1BQT is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BQT OCA].
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1BQT is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BQT OCA].
==Reference==
==Reference==
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[[Category: Growth factor]]
[[Category: Growth factor]]
[[Category: Insulin]]
[[Category: Insulin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 11:50:50 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 19:33:08 2008''

Revision as of 16:33, 30 June 2008

Image:1bqt.png

Template:STRUCTURE 1bqt

THREE-DIMENSIONAL STRUCTURE OF HUMAN INSULIN-LIKE GROWTH FACTOR-I (IGF-I) DETERMINED BY 1H-NMR AND DISTANCE GEOMETRY, 6 STRUCTURES

Template:ABSTRACT PUBMED 8391516

About this Structure

1BQT is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

Three-dimensional structure of human insulin-like growth factor-I (IGF-I) determined by 1H-NMR and distance geometry., Sato A, Nishimura S, Ohkubo T, Kyogoku Y, Koyama S, Kobayashi M, Yasuda T, Kobayashi Y, Int J Pept Protein Res. 1993 May;41(5):433-40. PMID:8391516

Page seeded by OCA on Mon Jun 30 19:33:08 2008

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