1br3

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[[Image:1br3.gif|left|200px]]
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{{STRUCTURE_1br3| PDB=1br3 | SCENE= }}
{{STRUCTURE_1br3| PDB=1br3 | SCENE= }}
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'''CRYSTAL STRUCTURE OF AN 82-NUCLEOTIDE RNA-DNA COMPLEX FORMED BY THE 10-23 DNA ENZYME'''
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===CRYSTAL STRUCTURE OF AN 82-NUCLEOTIDE RNA-DNA COMPLEX FORMED BY THE 10-23 DNA ENZYME===
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==Overview==
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The structure of a large nucleic acid complex formed by the 10-23 DNA enzyme bound to an RNA substrate was determined by X-ray diffraction at 3.0 A resolution. The 82-nucleotide complex contains two strands of DNA and two strands of RNA that form five double-helical domains. The spatial arrangement of these helices is maintained by two four-way junctions that exhibit extensive base-stacking interactions and sharp turns of the phosphodiester backbone stabilized by metal ions coordinated to nucleotides at these junctions. Although it is unlikely that the structure corresponds to the catalytically active conformation of the enzyme, it represents a novel nucleic acid fold with implications for the Holliday junction structure.
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(as it appears on PubMed at http://www.pubmed.gov), where 10048927 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10048927}}
==About this Structure==
==About this Structure==
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[[Category: Holliday junction]]
[[Category: Holliday junction]]
[[Category: Ribozyme]]
[[Category: Ribozyme]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 11:51:22 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 19:33:47 2008''

Revision as of 16:33, 30 June 2008

Image:1br3.png

Template:STRUCTURE 1br3

CRYSTAL STRUCTURE OF AN 82-NUCLEOTIDE RNA-DNA COMPLEX FORMED BY THE 10-23 DNA ENZYME

Template:ABSTRACT PUBMED 10048927

About this Structure

Full crystallographic information is available from OCA.

Reference

Crystal structure of an 82-nucleotide RNA-DNA complex formed by the 10-23 DNA enzyme., Nowakowski J, Shim PJ, Prasad GS, Stout CD, Joyce GF, Nat Struct Biol. 1999 Feb;6(2):151-6. PMID:10048927

Page seeded by OCA on Mon Jun 30 19:33:47 2008

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