1br9

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[[Image:1br9.gif|left|200px]]
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{{STRUCTURE_1br9| PDB=1br9 | SCENE= }}
{{STRUCTURE_1br9| PDB=1br9 | SCENE= }}
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'''HUMAN TISSUE INHIBITOR OF METALLOPROTEINASE-2'''
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===HUMAN TISSUE INHIBITOR OF METALLOPROTEINASE-2===
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==Overview==
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The three-dimensional structure of human tissue inhibitor of metalloproteinases-2 (TIMP-2) was determined by X-ray crystallography to 2.1 A resolution. The structure of the inhibitor consists of two domains. The N-terminal domain (residues 1-110) is folded into a beta-barrel, similar to the oligonucleotide/oligosaccharide binding fold otherwise found in certain DNA-binding proteins. The C-terminal domain (residues 111-194) contains a parallel stranded beta-hairpin plus a beta-loop-beta motif. Comparison of the structure of uncomplexed human TIMP-2 with that of bovine TIMP-2 bound to the catalytic domain of human MMP-14 suggests an internal rotation between the two domains of approximately 13 degrees upon binding to the protease. Furthermore, local conformational differences in the two structures that might be induced by formation of the protease-inhibitor complex have been found. The most prominent of these involves residues 27-40 of the A-B beta-hairpin loop. Structure-based alignment of amino acid sequences of representatives of the TIMP family maps the sequence differences mainly to loop regions, and some of these differences are proposed to be responsible for the particular properties of the various TIMP species.
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The line below this paragraph, {{ABSTRACT_PUBMED_9837731}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 9837731 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9837731}}
==About this Structure==
==About this Structure==
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[[Category: Tuuttila, A.]]
[[Category: Tuuttila, A.]]
[[Category: Proteinase inhibitor]]
[[Category: Proteinase inhibitor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 11:51:38 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 19:34:52 2008''

Revision as of 16:34, 30 June 2008

Image:1br9.png

Template:STRUCTURE 1br9

HUMAN TISSUE INHIBITOR OF METALLOPROTEINASE-2

Template:ABSTRACT PUBMED 9837731

About this Structure

1BR9 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Three-dimensional structure of human tissue inhibitor of metalloproteinases-2 at 2.1 A resolution., Tuuttila A, Morgunova E, Bergmann U, Lindqvist Y, Maskos K, Fernandez-Catalan C, Bode W, Tryggvason K, Schneider G, J Mol Biol. 1998 Dec 11;284(4):1133-40. PMID:9837731

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