1brv

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{{STRUCTURE_1brv| PDB=1brv | SCENE= }}
{{STRUCTURE_1brv| PDB=1brv | SCENE= }}
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'''SOLUTION NMR STRUCTURE OF THE IMMUNODOMINANT REGION OF PROTEIN G OF BOVINE RESPIRATORY SYNCYTIAL VIRUS, 48 STRUCTURES'''
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===SOLUTION NMR STRUCTURE OF THE IMMUNODOMINANT REGION OF PROTEIN G OF BOVINE RESPIRATORY SYNCYTIAL VIRUS, 48 STRUCTURES===
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==Overview==
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The three-dimensional solution structure of the immunodominant central conserved region of the attachment protein G (BRSV-G) of bovine respiratory syncytial virus has been determined by nuclear magnetic resonance (NMR) spectroscopy. In the 32-residue peptide studied, 19 residues form a small rigid core composed of two short helices, connected by a type I' turn, and linked by two disulfide bridges. This unique fold is among the smallest stable tertiary structures known and could therefore serve as an ideal building block for the design of de novo proteins and as a test case for modeling studies. A characteristic hydrophobic pocket, lined by conserved residues, lies at the surface of the peptide and may play a role in receptor binding. This work provides a structural basis for further peptide vaccine development against the severe diseases associated with the respiratory syncytial viruses in both cattle and man.
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(as it appears on PubMed at http://www.pubmed.gov), where 8942628 is the PubMed ID number.
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{{ABSTRACT_PUBMED_8942628}}
==About this Structure==
==About this Structure==
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1BRV is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bovine_respiratory_syncytial_virus Bovine respiratory syncytial virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BRV OCA].
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1BRV is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bovine_respiratory_syncytial_virus Bovine respiratory syncytial virus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BRV OCA].
==Reference==
==Reference==
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[[Category: Immunoglobulin-binding protein]]
[[Category: Immunoglobulin-binding protein]]
[[Category: Transmembrane]]
[[Category: Transmembrane]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 11:52:49 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 19:37:29 2008''

Revision as of 16:37, 30 June 2008

Image:1brv.png

Template:STRUCTURE 1brv

SOLUTION NMR STRUCTURE OF THE IMMUNODOMINANT REGION OF PROTEIN G OF BOVINE RESPIRATORY SYNCYTIAL VIRUS, 48 STRUCTURES

Template:ABSTRACT PUBMED 8942628

About this Structure

1BRV is a Single protein structure of sequence from Bovine respiratory syncytial virus. Full experimental information is available from OCA.

Reference

Solution structure of the immunodominant region of protein G of bovine respiratory syncytial virus., Doreleijers JF, Langedijk JP, Hard K, Boelens R, Rullmann JA, Schaaper WM, van Oirschot JT, Kaptein R, Biochemistry. 1996 Nov 26;35(47):14684-8. PMID:8942628

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