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1bs4

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{{STRUCTURE_1bs4| PDB=1bs4 | SCENE= }}
{{STRUCTURE_1bs4| PDB=1bs4 | SCENE= }}
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'''PEPTIDE DEFORMYLASE AS ZN2+ CONTAINING FORM (NATIVE) IN COMPLEX WITH INHIBITOR POLYETHYLENE GLYCOL'''
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===PEPTIDE DEFORMYLASE AS ZN2+ CONTAINING FORM (NATIVE) IN COMPLEX WITH INHIBITOR POLYETHYLENE GLYCOL===
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==Overview==
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Eubacterial proteins are synthesized with a formyl group at the N-terminus which is hydrolytically removed from the nascent chain by the mononuclear iron enzyme peptide deformylase. Catalytic efficiency strongly depends on the identity of the bound metal. We have determined by X-ray crystallography the Fe2+, Ni2+ and Zn2+ forms of the Escherichia coli enzyme and a structure in complex with the reaction product Met-Ala-Ser. The structure of the complex, with the tripeptide bound at the active site, suggests detailed models for the mechanism of substrate recognition and catalysis. Differences of the protein structures due to the identity of the bound metal are extremely small and account only for the observation that Zn2+ binds more tightly than Fe2+ or Ni2+. The striking loss of catalytic activity of the Zn2+ form could be caused by its reluctance to change between tetrahedral and five-fold metal coordination believed to occur during catalysis. N-terminal formylation and subsequent deformylation
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(as it appears on PubMed at http://www.pubmed.gov), where 9846875 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9846875}}
==About this Structure==
==About this Structure==
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[[Category: Iron metalloprotease]]
[[Category: Iron metalloprotease]]
[[Category: Protein synthesis]]
[[Category: Protein synthesis]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 11:53:28 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 19:38:13 2008''

Revision as of 16:38, 30 June 2008

Image:1bs4.png

Template:STRUCTURE 1bs4

PEPTIDE DEFORMYLASE AS ZN2+ CONTAINING FORM (NATIVE) IN COMPLEX WITH INHIBITOR POLYETHYLENE GLYCOL

Template:ABSTRACT PUBMED 9846875

About this Structure

1BS4 is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Iron center, substrate recognition and mechanism of peptide deformylase., Becker A, Schlichting I, Kabsch W, Groche D, Schultz S, Wagner AF, Nat Struct Biol. 1998 Dec;5(12):1053-8. PMID:9846875

Page seeded by OCA on Mon Jun 30 19:38:13 2008

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