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1bsx

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[[Image:1bsx.gif|left|200px]]
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{{Seed}}
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[[Image:1bsx.png|left|200px]]
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{{STRUCTURE_1bsx| PDB=1bsx | SCENE= }}
{{STRUCTURE_1bsx| PDB=1bsx | SCENE= }}
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'''STRUCTURE AND SPECIFICITY OF NUCLEAR RECEPTOR-COACTIVATOR INTERACTIONS'''
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===STRUCTURE AND SPECIFICITY OF NUCLEAR RECEPTOR-COACTIVATOR INTERACTIONS===
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==Overview==
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Combinatorial regulation of transcription implies flexible yet precise assembly of multiprotein regulatory complexes in response to signals. Biochemical and crystallographic analyses revealed that hormone binding leads to the formation of a hydrophobic groove within the ligand binding domain (LBD) of the thyroid hormone receptor that interacts with an LxxLL motif-containing alpha-helix from GRIP1, a coactivator. Residues immediately adjacent to the motif modulate the affinity of the interaction; the motif and the adjacent sequences are employed to different extents in binding to different receptors. Such interactions of amphipathic alpha-helices with hydrophobic grooves define protein interfaces in other regulatory complexes as well. We suggest that these common structural elements impart flexibility to combinatorial regulation, whereas side chains at the interface impart specificity.
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The line below this paragraph, {{ABSTRACT_PUBMED_9808622}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 9808622 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9808622}}
==About this Structure==
==About this Structure==
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[[Category: Nuclear receptor]]
[[Category: Nuclear receptor]]
[[Category: Specificity interaction site]]
[[Category: Specificity interaction site]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 11:55:08 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 19:40:25 2008''

Revision as of 16:40, 30 June 2008

Image:1bsx.png

Template:STRUCTURE 1bsx

STRUCTURE AND SPECIFICITY OF NUCLEAR RECEPTOR-COACTIVATOR INTERACTIONS

Template:ABSTRACT PUBMED 9808622

About this Structure

1BSX is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure and specificity of nuclear receptor-coactivator interactions., Darimont BD, Wagner RL, Apriletti JW, Stallcup MR, Kushner PJ, Baxter JD, Fletterick RJ, Yamamoto KR, Genes Dev. 1998 Nov 1;12(21):3343-56. PMID:9808622

Page seeded by OCA on Mon Jun 30 19:40:25 2008

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