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'''THE STRUCTURE OF AN HIV-1 SPECIFIC CELL ENTRY INHIBITOR IN COMPLEX WITH THE HIV-1 GP41 TRIMERIC CORE'''<br /> | '''THE STRUCTURE OF AN HIV-1 SPECIFIC CELL ENTRY INHIBITOR IN COMPLEX WITH THE HIV-1 GP41 TRIMERIC CORE'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1FAV is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http:// | + | 1FAV is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FAV OCA]. |
==Reference== | ==Reference== | ||
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[[Category: inhibitor]] | [[Category: inhibitor]] | ||
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Revision as of 13:46, 15 February 2008
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THE STRUCTURE OF AN HIV-1 SPECIFIC CELL ENTRY INHIBITOR IN COMPLEX WITH THE HIV-1 GP41 TRIMERIC CORE
Overview
The three-dimensional structure of the complex between an HIV-1 cell-entry, inhibitor selected from screening a combinatorial library of non-natural, building blocks and the central, trimeric, coiled-coil core of HIV-1 gp41, has been determined by X-ray crystallography. The biased combinatorial, library was designed to identify ligands binding in nonpolar pockets on, the surface of the coiled-coil core of gp41. The crystal structure shows, that the non-peptide moiety of the inhibitor binds to the targeted cavity, in two different binding modes. This result suggests a strategy for, increasing inhibitor potency by use of a second-generation combinatorial, library designed to give simultaneous occupancy of both binding sites.
About this Structure
1FAV is a Single protein structure of sequence from Human immunodeficiency virus 1. Full crystallographic information is available from OCA.
Reference
The structure of an HIV-1 specific cell entry inhibitor in complex with the HIV-1 gp41 trimeric core., Zhou G, Ferrer M, Chopra R, Kapoor TM, Strassmaier T, Weissenhorn W, Skehel JJ, Oprian D, Schreiber SL, Harrison SC, Wiley DC, Bioorg Med Chem. 2000 Sep;8(9):2219-27. PMID:11026535
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