1uuc
From Proteopedia
(New page: 200px<br /> <applet load="1uuc" size="450" color="white" frame="true" align="right" spinBox="true" caption="1uuc" /> '''SOLUTION STRUCTURE OF A CHIMERIC LEKTI-DOMA...) |
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==About this Structure== | ==About this Structure== | ||
| - | 1UUC is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1UUC OCA]]. | + | 1UUC is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]]. Structure known Active Site: PP1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1UUC OCA]]. |
==Reference== | ==Reference== | ||
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[[Category: serine proteinase inhibitor]] | [[Category: serine proteinase inhibitor]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 11:25:25 2007'' |
Revision as of 09:20, 30 October 2007
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SOLUTION STRUCTURE OF A CHIMERIC LEKTI-DOMAIN
Overview
The conversion of an alpha-helical to a beta-strand conformation and the, presence of chameleon sequences are fascinating from the perspective that, such structural features are implicated in the induction of, amyloid-related fatal diseases. In this study, we have determined the, solution structure of a chimeric domain (Dom1PI) from the multidomain, Kazal-type serine proteinase inhibitor LEKTI using multidimensional NMR, spectroscopy. This chimeric protein was constructed to investigate the, reasons for differences in the folds of the homologous LEKTI domains 1 and, 6 [Lauber, T., et al. (2003) J. Mol. Biol. 328, 205-219]. In Dom1PI, two, adjacent phenylalanine residues (F28 and F29) of domain 1 were substituted, with proline and isoleucine, respectively, as found in the corresponding, ... [(full description)]
About this Structure
1UUC is a [Single protein] structure of sequence from [Homo sapiens]. Structure known Active Site: PP1. Full crystallographic information is available from [OCA].
Reference
The solution structure of a chimeric LEKTI domain reveals a chameleon sequence., Tidow H, Lauber T, Vitzithum K, Sommerhoff CP, Rosch P, Marx UC, Biochemistry. 2004 Sep 7;43(35):11238-47. PMID:15366933
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