1buy

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{{Seed}}
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{{STRUCTURE_1buy| PDB=1buy | SCENE= }}
{{STRUCTURE_1buy| PDB=1buy | SCENE= }}
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'''HUMAN ERYTHROPOIETIN, NMR MINIMIZED AVERAGE STRUCTURE'''
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===HUMAN ERYTHROPOIETIN, NMR MINIMIZED AVERAGE STRUCTURE===
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==Overview==
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The solution structure of human erythropoietin (EPO) has been determined by nuclear magnetic resonance spectroscopy and the overall topology of the protein is revealed as a novel combination of features taken from both the long-chain and short-chain families of hematopoietic growth factors. Using the structure and data from mutagenesis studies we have elucidated the key physiochemical properties defining each of the two receptor binding sites on the EPO protein. A comparison of the NMR structure of the free EPO ligand to the receptor bound form, determined by X-ray crystallography, reveals conformational changes that may accompany receptor binding.
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The line below this paragraph, {{ABSTRACT_PUBMED_9783743}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 9783743 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9783743}}
==About this Structure==
==About this Structure==
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1BUY is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BUY OCA].
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1BUY is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BUY OCA].
==Reference==
==Reference==
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[[Category: Glycoprotein]]
[[Category: Glycoprotein]]
[[Category: Growth factor]]
[[Category: Growth factor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 11:59:07 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 19:45:33 2008''

Revision as of 16:45, 30 June 2008

Image:1buy.png

Template:STRUCTURE 1buy

HUMAN ERYTHROPOIETIN, NMR MINIMIZED AVERAGE STRUCTURE

Template:ABSTRACT PUBMED 9783743

About this Structure

1BUY is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

NMR structure of human erythropoietin and a comparison with its receptor bound conformation., Cheetham JC, Smith DM, Aoki KH, Stevenson JL, Hoeffel TJ, Syed RS, Egrie J, Harvey TS, Nat Struct Biol. 1998 Oct;5(10):861-6. PMID:9783743

Page seeded by OCA on Mon Jun 30 19:45:33 2008

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