1bvs

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[[Image:1bvs.gif|left|200px]]
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{{STRUCTURE_1bvs| PDB=1bvs | SCENE= }}
{{STRUCTURE_1bvs| PDB=1bvs | SCENE= }}
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'''RUVA COMPLEXED TO A HOLLIDAY JUNCTION.'''
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===RUVA COMPLEXED TO A HOLLIDAY JUNCTION.===
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==Overview==
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Holliday junctions occur as intermediates in homologous recombination and DNA repair. In bacteria, resolution of Holliday junctions is accomplished by the RuvABC system, consisting of a junction-specific helicase complex RuvAB, which promotes branch migration, and a junction-specific endonuclease RuvC, which nicks two strands. The crystal structure of a complex between the RuvA protein of M. leprae and a synthetic four-way junction has now been determined. Rather than binding on the open surface of a RuvA tetramer as previously suggested, the DNA is sandwiched between two RuvA tetramers, which form a closed octameric shell, stabilized by a conserved tetramer-tetramer interface. Interactions between the DNA backbone and helix-hairpin-helix motifs from both tetramers suggest a mechanism for strand separation promoted by RuvA.
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(as it appears on PubMed at http://www.pubmed.gov), where 9774974 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9774974}}
==About this Structure==
==About this Structure==
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[[Category: Dna repair]]
[[Category: Dna repair]]
[[Category: Holliday junction resolvase component]]
[[Category: Holliday junction resolvase component]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 12:00:49 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 19:47:50 2008''

Revision as of 16:47, 30 June 2008

Image:1bvs.png

Template:STRUCTURE 1bvs

RUVA COMPLEXED TO A HOLLIDAY JUNCTION.

Template:ABSTRACT PUBMED 9774974

About this Structure

1BVS is a Single protein structure of sequence from Mycobacterium leprae. Full crystallographic information is available from OCA.

Reference

Crystal structure of an octameric RuvA-Holliday junction complex., Roe SM, Barlow T, Brown T, Oram M, Keeley A, Tsaneva IR, Pearl LH, Mol Cell. 1998 Sep;2(3):361-72. PMID:9774974

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