6iva

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==Crystal structure of the S. typhimurium oxaloacetate decarboxylase beta-gamma sub-complex==
==Crystal structure of the S. typhimurium oxaloacetate decarboxylase beta-gamma sub-complex==
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<StructureSection load='6iva' size='340' side='right'caption='[[6iva]]' scene=''>
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<StructureSection load='6iva' size='340' side='right'caption='[[6iva]], [[Resolution|resolution]] 4.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IVA OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6IVA FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6iva]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Salet Salet]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IVA OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6IVA FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6iva FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6iva OCA], [http://pdbe.org/6iva PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6iva RCSB], [http://www.ebi.ac.uk/pdbsum/6iva PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6iva ProSAT]</span></td></tr>
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</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Oxaloacetate_decarboxylase_(Na(+)_extruding) Oxaloacetate decarboxylase (Na(+) extruding)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=7.2.4.2 7.2.4.2] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6iva FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6iva OCA], [http://pdbe.org/6iva PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6iva RCSB], [http://www.ebi.ac.uk/pdbsum/6iva PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6iva ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/A0A0F7JAV8_SALTM A0A0F7JAV8_SALTM]] Catalyzes the decarboxylation of oxaloacetate coupled to Na(+) translocation.[PIRNR:PIRNR015658] [[http://www.uniprot.org/uniprot/A0A0D6I9X5_SALTM A0A0D6I9X5_SALTM]] Catalyzes the decarboxylation of oxaloacetate coupled to Na(+) translocation.[HAMAP-Rule:MF_00404][RuleBase:RU004278]
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The oxaloacetate decarboxylase sodium pump (OAD) is a unique primary-active transporter that utilizes the free energy derived from oxaloacetate decarboxylation for sodium transport across the cell membrane. It is composed of 3 subunits: the alpha subunit catalyzes carboxyl-transfer from oxaloacetate to biotin, the membrane integrated beta subunit catalyzes the subsequent carboxyl-biotin decarboxylation and the coupled sodium transport, the gamma subunit interacts with the alpha and beta subunits and stabilizes the OAD complex. We present here structure of the Salmonella typhimurium OAD betagamma sub-complex. The structure revealed that the beta and gamma subunits form a beta3gamma3 hetero-hexamer with extensive interactions between the subunits and shed light on the OAD holo-enzyme assembly. Structure-guided functional studies provided insights into the sodium binding sites in the beta subunit and the coupling between carboxyl-biotin decarboxylation and sodium transport by the OAD beta subunit.
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Structural insights into sodium transport by the oxaloacetate decarboxylase sodium pump.,Xu X, Shi H, Gong X, Chen P, Gao Y, Zhang X, Xiang S Elife. 2020 May 27;9. pii: 53853. doi: 10.7554/eLife.53853. PMID:32459174<ref>PMID:32459174</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 6iva" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Xiang S]]
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[[Category: Salet]]
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[[Category: Xu X]]
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[[Category: Xiang, S]]
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[[Category: Xu, X]]
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[[Category: Biotin-dependent decarboxylase]]
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[[Category: Decarboxylase sodium pump]]
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[[Category: Membrane protein]]

Revision as of 05:58, 20 January 2021

Crystal structure of the S. typhimurium oxaloacetate decarboxylase beta-gamma sub-complex

PDB ID 6iva

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