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6wcd

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Current revision (14:21, 18 October 2023) (edit) (undo)
 
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<StructureSection load='6wcd' size='340' side='right'caption='[[6wcd]], [[Resolution|resolution]] 1.54&Aring;' scene=''>
<StructureSection load='6wcd' size='340' side='right'caption='[[6wcd]], [[Resolution|resolution]] 1.54&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6wcd]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/African_clawed_frog African clawed frog]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6WCD OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6WCD FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6wcd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6WCD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6WCD FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BU1:1,4-BUTANEDIOL'>BU1</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.54&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5u6z|5u6z]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BU1:1,4-BUTANEDIOL'>BU1</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">apex2, apex2-prov ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=8355 African clawed frog])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6wcd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6wcd OCA], [https://pdbe.org/6wcd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6wcd RCSB], [https://www.ebi.ac.uk/pdbsum/6wcd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6wcd ProSAT]</span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA-(apurinic_or_apyrimidinic_site)_lyase DNA-(apurinic or apyrimidinic site) lyase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.99.18 4.2.99.18] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6wcd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6wcd OCA], [http://pdbe.org/6wcd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6wcd RCSB], [http://www.ebi.ac.uk/pdbsum/6wcd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6wcd ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/Q6DDT4_XENLA Q6DDT4_XENLA]] Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.[RuleBase:RU362131]
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[https://www.uniprot.org/uniprot/Q6DDT4_XENLA Q6DDT4_XENLA] Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.[RuleBase:RU362131]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 6wcd" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 6wcd" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Apurinic/apyrimidinic endonuclease 3D structures|Apurinic/apyrimidinic endonuclease 3D structures]]
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*[[Endonuclease 3D structures|Endonuclease 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: African clawed frog]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Wallace, B D]]
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[[Category: Xenopus laevis]]
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[[Category: Williams, R S]]
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[[Category: Wallace BD]]
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[[Category: Wojtaszek, J L]]
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[[Category: Williams RS]]
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[[Category: Dna repair]]
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[[Category: Wojtaszek JL]]
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[[Category: Hydrolase]]
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[[Category: Nuclease]]
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Current revision

Crystal Structure of Xenopus laevis APE2 Catalytic Domain

PDB ID 6wcd

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