1by1

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[[Image:1by1.gif|left|200px]]
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{{STRUCTURE_1by1| PDB=1by1 | SCENE= }}
{{STRUCTURE_1by1| PDB=1by1 | SCENE= }}
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'''DBL homology domain from beta-PIX'''
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===DBL homology domain from beta-PIX===
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==Overview==
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Guanine nucleotide exchange factors in the Dbl family activate Rho GTPases by accelerating dissociation of bound GDP, promoting acquisition of the GTP-bound state. Dbl proteins possess a approximately 200 residue catalytic Dbl-homology (DH) domain, that is arranged in tandem with a C-terminal pleckstrin homology (PH) domain in nearly all cases. Here we report the solution structure of the DH domain of human PAK-interacting exchange protein (betaPIX). The domain is composed of 11 alpha-helices that form a flattened, elongated bundle. The structure explains a large body of mutagenesis data, which, along with sequence comparisons, identify the GTPase interaction site as a surface formed by three conserved helices near the center of one face of the domain. Proximity of the site to the DH C-terminus suggests a means by which PH-ligand interactions may be coupled to DH-GTPase interactions to regulate signaling through the Dbl proteins in vivo.
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{{ABSTRACT_PUBMED_9846881}}
==About this Structure==
==About this Structure==
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1BY1 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BY1 OCA].
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1BY1 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BY1 OCA].
==Reference==
==Reference==
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[[Category: Zhu, K.]]
[[Category: Zhu, K.]]
[[Category: Rho-gtpase exchange factor]]
[[Category: Rho-gtpase exchange factor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 19:53:56 2008''

Revision as of 16:53, 30 June 2008

Image:1by1.png

Template:STRUCTURE 1by1

DBL homology domain from beta-PIX

Template:ABSTRACT PUBMED 9846881

About this Structure

1BY1 is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

Structure and mutagenesis of the Dbl homology domain., Aghazadeh B, Zhu K, Kubiseski TJ, Liu GA, Pawson T, Zheng Y, Rosen MK, Nat Struct Biol. 1998 Dec;5(12):1098-107. PMID:9846881

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