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2vsr

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Revision as of 11:45, 30 March 2022

hPPARgamma Ligand binding domain in complex with 9-(S)-HODE

Structural highlights

2vsr is a 2 chain structure with sequence from Human. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:
Related:	2fvj, 2vv2, 1fm9, 2vv0, 2vv1, 2prg, 1knu, 1rdt, 3prg, 2vv4, 1i7i, 1k74, 1fm6, 1zgy, 1prg, 2f4b, 2vst, 2g0h, 1wm0, 4prg, 2vv3, 1nyx, 2g0g
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

The nuclear receptor peroxisome proliferator-activated receptor-gamma (PPARgamma) has important roles in adipogenesis and immune response as well as roles in both lipid and carbohydrate metabolism. Although synthetic agonists for PPARgamma are widely used as insulin sensitizers, the identity of the natural ligand(s) for PPARgamma is still not clear. Suggested natural ligands include 15-deoxy-delta12,14-prostaglandin J2 and oxidized fatty acids such as 9-HODE and 13-HODE. Crystal structures of PPARgamma have revealed the mode of recognition for synthetic compounds. Here we report structures of PPARgamma bound to oxidized fatty acids that are likely to be natural ligands for this receptor. These structures reveal that the receptor can (i) simultaneously bind two fatty acids and (ii) couple covalently with conjugated oxo fatty acids. Thermal stability and gene expression analyses suggest that such covalent ligands are particularly effective activators of PPARgamma and thus may serve as potent and biologically relevant ligands.

Structural basis for the activation of PPARgamma by oxidized fatty acids.,Itoh T, Fairall L, Amin K, Inaba Y, Szanto A, Balint BL, Nagy L, Yamamoto K, Schwabe JW Nat Struct Mol Biol. 2008 Sep;15(9):924-31. PMID:19172745^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Itoh T, Fairall L, Amin K, Inaba Y, Szanto A, Balint BL, Nagy L, Yamamoto K, Schwabe JW. Structural basis for the activation of PPARgamma by oxidized fatty acids. Nat Struct Mol Biol. 2008 Sep;15(9):924-31. PMID:19172745

1 Structural highlights
2 Evolutionary Conservation
3 Publication Abstract from PubMed
4 See Also
5 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2vsr"

@@ Line 3: / Line 3: @@
 <StructureSection load='2vsr' size='340' side='right'caption='[[2vsr]], [[Resolution|resolution]] 2.05&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[2vsr]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VSR OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2VSR FirstGlance]. <br>
+<table><tr><td colspan='2'>[[2vsr]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VSR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VSR FirstGlance]. <br>
 </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=9HO:(9S,10E,12Z)-9-HYDROXYOCTADECA-10,12-DIENOIC+ACID'>9HO</scene></td></tr>
-<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2fvj|2fvj]], [[2vv2|2vv2]], [[1fm9|1fm9]], [[2vv0|2vv0]], [[2vv1|2vv1]], [[2prg|2prg]], [[1knu|1knu]], [[1rdt|1rdt]], [[3prg|3prg]], [[2vv4|2vv4]], [[1i7i|1i7i]], [[1k74|1k74]], [[1fm6|1fm6]], [[1zgy|1zgy]], [[1prg|1prg]], [[2f4b|2f4b]], [[2vst|2vst]], [[2g0h|2g0h]], [[1wm0|1wm0]], [[4prg|4prg]], [[2vv3|2vv3]], [[1nyx|1nyx]], [[2g0g|2g0g]]</td></tr>
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2fvj|2fvj]], [[2vv2|2vv2]], [[1fm9|1fm9]], [[2vv0|2vv0]], [[2vv1|2vv1]], [[2prg|2prg]], [[1knu|1knu]], [[1rdt|1rdt]], [[3prg|3prg]], [[2vv4|2vv4]], [[1i7i|1i7i]], [[1k74|1k74]], [[1fm6|1fm6]], [[1zgy|1zgy]], [[1prg|1prg]], [[2f4b|2f4b]], [[2vst|2vst]], [[2g0h|2g0h]], [[1wm0|1wm0]], [[4prg|4prg]], [[2vv3|2vv3]], [[1nyx|1nyx]], [[2g0g|2g0g]]</div></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2vsr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vsr OCA], [http://pdbe.org/2vsr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2vsr RCSB], [http://www.ebi.ac.uk/pdbsum/2vsr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2vsr ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vsr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vsr OCA], [https://pdbe.org/2vsr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vsr RCSB], [https://www.ebi.ac.uk/pdbsum/2vsr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vsr ProSAT]</span></td></tr>
 </table>
 == Evolutionary Conservation ==
@@ Line 29: / Line 29: @@
 ==See Also==
-*[[Phenylethanolamine N-methyltransferase 3D structures|Phenylethanolamine N-methyltransferase 3D structures]]
+*[[Peroxisome proliferator-activated receptor 3D structures|Peroxisome proliferator-activated receptor 3D structures]]
 == References ==
 <references/>

2vsr

From Proteopedia

Revision as of 11:45, 30 March 2022

hPPARgamma Ligand binding domain in complex with 9-(S)-HODE

Structural highlights

Evolutionary Conservation

Publication Abstract from PubMed

See Also

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

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