1by6

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{{STRUCTURE_1by6| PDB=1by6 | SCENE= }}
{{STRUCTURE_1by6| PDB=1by6 | SCENE= }}
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'''PEPTIDE OF HUMAN APOLIPOPROTEIN C-II'''
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===PEPTIDE OF HUMAN APOLIPOPROTEIN C-II===
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==Overview==
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We have studied the three-dimensional structure of a biologically active peptide of apolipoprotein C-II (apoC-II) in the presence of lipid mimetics by CD and NMR spectroscopy. This peptide, corresponding to residues 44-79 of apoC-II, has been shown to reverse the symptoms of genetic apoC-II deficiency in a human subject. A comparison of alpha-proton secondary shifts and CD spectroscopic data indicates that the structure of apoC-II(44-79) is similar in the presence of dodecylphosphocholine and sodium dodecyl sulfate. The three-dimensional structure of apoC-II(44-79) in the presence of sodium dodecyl sulfate, determined by relaxation matrix calculations, contains two amphipathic helical domains formed by residues 50-58 and 67-75, separated by a non-helical linker centered at Tyr63. The C-terminal helix is terminated by a loop formed by residues 76-79. The C-terminal helix is better defined and has a larger hydrophobic face than the N-terminal helix, which leads us to propose that the C-terminal helix together with the non-helical Ile66 constitute the primary lipid binding domain of apoC-II(44-79). Based on our structure we suggest a new mechanism of lipoprotein lipase activation in which both helices of apoC-II(44-79) remain lipid bound, while the seven-residue interhelical linker extends away from the lipid surface in order to project Tyr63 into the apoC-II binding site of lipoprotein lipase.
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(as it appears on PubMed at http://www.pubmed.gov), where 10903476 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10903476}}
==About this Structure==
==About this Structure==
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1BY6 is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BY6 OCA].
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1BY6 is a [[Single protein]] structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BY6 OCA].
==Reference==
==Reference==
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[[Category: Lipid association]]
[[Category: Lipid association]]
[[Category: Lpl activation]]
[[Category: Lpl activation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 12:06:25 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 19:54:17 2008''

Revision as of 16:54, 30 June 2008

Image:1by6.png

Template:STRUCTURE 1by6

PEPTIDE OF HUMAN APOLIPOPROTEIN C-II

Template:ABSTRACT PUBMED 10903476

About this Structure

1BY6 is a Single protein structure. Full experimental information is available from OCA.

Reference

Structure of a biologically active fragment of human serum apolipoprotein C-II in the presence of sodium dodecyl sulfate and dodecylphosphocholine., Storjohann R, Rozek A, Sparrow JT, Cushley RJ, Biochim Biophys Acta. 2000 Jul 19;1486(2-3):253-64. PMID:10903476

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